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首页> 外文期刊>Journal of Cellular Physiology >Spindle orientation in animal cell mitosis: roles of integrin in the control of spindle axis.
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Spindle orientation in animal cell mitosis: roles of integrin in the control of spindle axis.

机译：主轴定位在动物细胞有丝分裂:角色整合素的主轴的控制。

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The orientation of mitotic spindles, which determines the plane of cell division, is tightly regulated in polarized cells such as epithelial cells, but it has been unclear whether there is a mechanism regulating spindle orientation in non-polarized cultured cells. In adherent cultured cells, spindles are positioned at the center of the cells and the axis of the spindle lies in the longest axis of the cell. Thus, cell geometry is thought to be one of cues for spindle orientation and positioning in cultured cells because this defines the center and the long axis of the cell. Recent work provides a new insight into the spindle orientation in cultured cells; spindles are aligned along the axis parallel to the cell-substrate adhesion plane. Concomitantly, integrin-mediated cell adhesion to the extracellular matrix (ECM), rather than gravitation, cell-cell adhesion or cell geometry, has shown to be essential for this mechanism of spindle orientation. Several independent lines of evidence confirm the involvement of cell-ECM adhesion in spindle orientation in both cultured cells and in developing organisms. The important future challenge is to identify a molecular mechanism(s) that links integrin and spindles in the control of spindle axis.
机译：有丝分裂纺锤波的方向确定平面的细胞分裂,紧密监管在极化细胞如上皮细胞,但不清楚是否有机制调节主轴方向无极培养细胞。培养细胞,位于纺锤波中心的细胞和轴的轴线在于细胞的最长轴。几何被认为是主轴的线索定向和定位在培养细胞因为这个定义了中心和长轴的细胞。在培养细胞到主轴取向;沿着轴平行纺锤波是一致的细胞基质粘附平面。integrin-mediated细胞粘附细胞外基质(ECM),而不是万有引力、信息粘连或细胞几何、已经显示出对这种机制是必要的主轴方向。证据证实cell-ECM的参与粘附在主轴方向培养细胞和在发展中生物。未来的挑战是确定一个分子机制的整合素和纺锤波的链接主轴的控制。

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