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首页> 外文期刊>Journal of Cellular Physiology >MT1-MMP: a potent modifier of pericellular microenvironment.
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MT1-MMP: a potent modifier of pericellular microenvironment.

机译：MT1-MMP: pericellular的有力修饰符微环境。

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摘要

Cells are regulated by many different means, and there is more and more evidence emerging that changes in the microenvironment greatly affect cell function. MT1-MMP is a type I transmembrane proteinase which participates in pericellular proteolysis of extracellular matrix (ECM) macromolecules. The enzyme is cellular collagenase essential for skeletal development, cancer invasion, growth, and angiogenesis. MT1-MMP promotes cell invasion and motility by pericellular ECM degradation, shedding of CD44 and syndecan1, and by activating ERK. Thus MT1-MMP is one of the factors that influence the cellular microenvironment and thereby affect cell-signaling pathways and eventually alters cellular behavior. As a proteinase, MT1-MMP is regulated by inhibitors, but it also requires formation of a homo-oligomer complex, localization to migration front of the cells, and internalization to become a "functionally active" cell function modifier. Developing new means to inhibit "functional activity" of MT1-MMP may be a new direction to establish treatments for the diseases that MT1-MMP mediates such as cancer and rheumatoid arthritis.
机译：细胞是由许多不同的含义,以及有越来越多的证据出现微环境的变化极大地影响细胞的功能。参与pericellular蛋白酶蛋白水解作用的细胞外基质(ECM)大分子。骨骼发育所必需的胶原酶,癌症入侵、生长和血管生成。MT1-MMP促进细胞入侵和能动性pericellular ECM降解,CD44,和通过激活ERK syndecan1。MT1-MMP是影响的因素之一细胞微环境,从而影响细胞信号通路,最终改变细胞的行为。受抑制剂,但它也需要组建一个homo-oligomer复杂,迁移前的细胞定位内化成为“功能活跃”细胞功能修饰符。抑制”MT1-MMP可能的功能活动”建立治疗的新方向MT1-MMP调和的疾病如癌症和类风湿性关节炎。

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