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首页> 外文期刊>Current drug research reviews. >Therapeutic Potential of Antileukotriene Drug-Camellia sinensis Extract Co-Formulation on Histamine Induced Asthma in Guinea Pigs
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Therapeutic Potential of Antileukotriene Drug-Camellia sinensis Extract Co-Formulation on Histamine Induced Asthma in Guinea Pigs

机译：治疗的潜力AntileukotrieneDrug-Camellia sinensis提取Co-Formulation在豚鼠组胺诱发哮喘

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Background/Objective: To study the therapeutic potential of Antileukotriene drug-Camellia sinensis extract co-formulation on histamine induced asthma in guinea pigs.Methods: SRSD of Montelukast sodium was prepared by the solvent evaporation method. Lyophil-ized aqueous extract of Camellia sinensis leaves and SRSD mixture was filled in capsule and the capsule shell was coated to achieve initial release lag time. In vitro and pharmacokinetic study of capsules was performed and compared with commercial tablets. A further role of green tea, as an antioxidant adjunct for asthma management, has been analyzed by lung histology, mast cell count and oxidative stress assay in the serum of control and experimental animals.Results: The drug release from the commercial tablet was immediate and rapid, but capsule has shown an initial 3.5 hr lag time followed by sustained action up to 8 hr. Pharmacokinetic results show that studied formulations are bioequivalent with respect to Cmax and AUC, while rest parameters showed asignificant difference. Mast cells count in lung tissue were increased (p<0.001) in the experimental group along with glycoprotein deposition in asthmatic bronchioles. Levels of SOD and GPX were decreased (p<0.05) while CAT was increased (p<0.04) in the asthma group in comparison to control.Conclusion: In the experimental animal model, co-formulation was effective in modulating allergic inflammation and contributing to better control of the inflammatory response. Our findings suggest that Camellia sinensis leaves extract may be used as an adjunct for future improvements in asthma treatment and prevention.
机译：背景/目的:研究治疗的潜力Antileukotriene drug-Camelliasinensis提取co-formulation组胺在豚鼠诱发哮喘。Montelukast钠是由溶剂蒸发的方法。茶树的叶子和SRSD混合物填充胶囊,胶囊壳涂层达到最初版本滞后时间。体外和胶囊的药代动力学研究执行并与商业的平板电脑。进一步的绿茶的作用,是一种抗氧化剂兼职对哮喘管理,分析了通过肺组织学,肥大细胞数和氧化控制和应力测定血清实验动物。从商业平板电脑是直接的和快速,但胶囊显示初始3.5人力资源延迟时间之后,持续8小时行动。药代动力学研究结果表明,bioequivalent对配方Cmax和AUC,而其他参数显示乳癌的区别。组织中增加(p < 0.001)实验组以及糖蛋白沉积在哮喘细支气管。SOD、GPX下降(p < 0.05),而猫增加哮喘组(p < 0.04)比较来控制。实验动物模型,co-formulation有效地调节炎症和过敏有助于更好的控制炎症反应。茶树叶子提取物可能用作兼职对未来改善哮喘治疗和预防。

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