Regulation of protein phosphatase 2A-mediated recruitment of IQGAP1 to beta1 integrin by EGF through activation of Ca2+/calmodulin-dependent protein kinase II.

Takahashi K; Suzuki K

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Regulation of protein phosphatase 2A-mediated recruitment of IQGAP1 to beta1 integrin by EGF through activation of Ca2+/calmodulin-dependent protein kinase II.

机译：调节蛋白磷酸酶2一个调解的通过EGF招聘的IQGAP1 beta1整合素通过激活Ca2 + / calmodulin-dependent蛋白激酶二世。

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Maintenance of beta1 integrin-mediated cell adhesion in quiescent human mammary epithelial (HME) cells requires protein phosphatase (PP) 2A for not only dephosphorylation of beta1 integrin but also recruitment of IQGAP1 to Rac-bound beta1 integrin. However, how PP2A-dependent regulatory machinery of cell adhesion responds to EGF remains to be elucidated. We report here that phosphorylated Ca2+/calmodulin-dependent protein kinase II (CaMKII) at threonine 286 was involved in the beta1 integrin complex that consisted of PP2A, Rac, and IQGAP1 in quiescent HME cells. Stimulation of the cells with EGF concomitantly induced an increase in intracellular Ca2+, activation of CaMKII, and dissociation of PP2A-IQGAP1-CaMKII from beta1 integrin-Rac. Because the activation of CaMKII and dissociation of PP2A-IQGAP1-CaMKII were blocked by either Ca2+-chelator or CaMKII inhibitor, we therefore propose that EGF has the ability to abrogate the PP2A function in the maintenance of beta1 integrin-mediated cell adhesion by dissociation of PP2A-IQGAP1-CaMKII from beta1 integrin-Rac through activation of CaMKII.

机译：维护beta1 integrin-mediated细胞人类乳腺上皮细胞粘附在静止(HME)细胞需要蛋白质磷酸酶(PP) 2 a不仅去磷酸化的beta1整合素还招聘IQGAP1 Rac-bound beta1整合素。细胞粘附响应EGF的机械还有待阐明。磷酸化Ca2 + / calmodulin-dependent蛋白质在苏氨酸激酶2 (CaMKII) 286年在beta1整合素是复杂的PP2A Rac, IQGAP1在静止HME细胞。刺激细胞EGF相符诱导细胞内钙离子的增加,CaMKII的激活,离解从beta1 PP2A-IQGAP1-CaMKII integrin-Rac。因为CaMKII的激活和离解PP2A-IQGAP1-CaMKII被封锁的钙离子螯合剂或CaMKII抑制剂,因此我们建议EGF可以废除在维护beta1 PP2A函数通过分离integrin-mediated细胞粘附的PP2A-IQGAP1-CaMKII beta1 integrin-Rac通过CaMKII的激活。

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来源
《Journal of Cellular Physiology》 |2006年第1期|213-219|共7页
作者
Takahashi K; Suzuki K;
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作者单位

Molecular Cell Biology Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan. ktaka@gancen.asahi.yokohama.jp;

sl.ap-hop-paris.fr;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
CD29 Antigen; Calmodulin-Dependent Protein Kinase II; Protein Phosphatase 2ITGB1 geneCell AdhesionIntegrinsEGF Family of ProteinsCalcium-Calmodulin-Dependent Protein Kinases;

机译：CD29抗原;Calmodulin-Dependent蛋白激酶AdhesionIntegrinsEGF家族ProteinsCalcium-Calmodulin-Dependent蛋白质激酶;

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Regulation of protein phosphatase 2A-mediated recruitment of IQGAP1 to beta1 integrin by EGF through activation of Ca2+/calmodulin-dependent protein kinase II.

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