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首页> 外文期刊>Journal of Cellular Physiology >Transcriptome profiling in clinical breast cancer: from 3D culture models to prognostic signatures.
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Transcriptome profiling in clinical breast cancer: from 3D culture models to prognostic signatures.

机译：转录组分析在临床乳腺癌:从3 d文化模型预后签名。

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Early detection has been one of the most effective strategies to control the growing cancer burden. The power of earlier detection has been demonstrated by the impact of pap-smear, mammography, and PSA tests on cancer patient treatment and survival. These tests benefit patients independent of their genetic background or race. However, in many cases, we are still losing the battle against cancer because patients that initially presented with low-grade disease progress rapidly to aggressive forms of the disease. As of yet, we have limited means to predict a particular patient's fate or to specifically treat subtypes of cancer. A combination of earlier detection and targeted therapy, based on information from transcriptome analysis, could be a powerful ally in this battle. The theme of this review article is to briefly summarize innovative strategies using three-dimensional (3D) cell cultures of human mammary epithelial cells to predict clinical outcome in breast cancer. This strategy has the potential tofurther enhance our understanding of breast cancer biology and to contribute to the identification of biologically significant bio-markers that are also useful drug targets.
机译：早期检测一直是最有效的策略来控制不断增长的癌症负担。早期检测的力量证明了子宫颈抹片检查的影响,乳房x光检查,对癌症病人PSA测试治疗和生存。患者独立的遗传背景或种族。因为病人失去对抗癌症最初出现低级的疾病进展迅速,激进的形式的疾病。预测一个特定的病人或命运专门治疗癌症亚型。早期检测和目标的组合从转录组治疗,根据信息分析,可能是一个强大的盟友战斗。简要总结创新的策略使用人类的三维(3 d)细胞培养乳腺上皮细胞预测临床结果在乳腺癌。潜在的应用提高我们理解乳腺癌生物学和作出贡献识别生物学上重要的生物标志物,也有用的药物靶点。

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