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Dithranol: An Insight into its Novel Delivery Cargos for Psoriasis Management

机译：蒽三酚:了解其小说交付牛皮癣管理货物

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摘要

Objective: Dithranol (DTH) is a well-known moiety that has long been used promisingly to impede and treat skin disorders, particularly psoriasis. Nowadays, a rekindled interest in the use of DTH for this disorder has been observed. Side effects associated with conventional topical formulations of this moiety have aroused the interest of the scientific community in investigating novel cargos of DTH for psoriasis management. Results: Previous research has evidenced the anti-inflammatory and anti-proliferating potential of DTH. Numerous studies have indicated that DTH inhibits polymorphonuclear (PMN) leucocyte, modulates epidermal cell receptors and promotes anti-psoriatic action. However, some deterrent factors like poor solubility, stability, toxicity, staining and skin irritation hamper its use as a potential therapeutic agent. With the adoption of novel drug delivery technologies, the above mentioned inherent limitations of DTH have been compensated to reestablish this drug moiety. Conclusion: This article reviews novel drug delivery aspects, safety concerns, clinical evidence, current status, and future opportunities of DTH in the management of psoriasis. Further, it will update researchers on this promising drug moiety, which is free from systemic adverse responses in comparison to other therapeutic molecules like steroids, for psoriasis treatment.
机译：摘要目的:蒽三酚(DTH)是一个著名的一部分一直充满希望地阻碍和使用治疗皮肤疾病,尤其是牛皮癣。如今,重燃兴趣DTH的使用对于这个障碍已经被观察到。与传统的外用制剂这一部分已经引起了的兴趣科学界在调查的小说货物的DTH牛皮癣管理。先前的研究已经证明抗炎和anti-proliferating潜的潜力。DTH抑制多形核中性粒细胞)白细胞,调节表皮细胞受体和促进anti-psoriatic行动。威慑因素像可怜的溶解度,稳定、毒性、染色和皮肤过敏阻碍它的使用作为一个潜在的治疗。采用新型药物输送技术,上述固有的DTH已补偿的局限性重建这药一半。文章评论小说药物输送方面,安全问题,临床证据,电流潜的状态和未来的机会牛皮癣的管理。研究人员在这个有前途的药物一半从系统性不良反应是免费的吗相比其它治疗分子类固醇,牛皮癣治疗。

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