...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cellular Physiology >Passive osmotic properties of in situ human articular chondrocytes within non-degenerate and degenerate cartilage.
【24h】

Passive osmotic properties of in situ human articular chondrocytes within non-degenerate and degenerate cartilage.

机译：被动原位渗透性能的人关节软骨细胞在非简并退化软骨。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Osteoarthritis is characterized by many factors, including proteoglycan loss, decreased collagen stiffness, and increased cartilage hydration. Chondrocyte swelling also occurs, and correlates with the degree of osteoarthritis, however, the cause is unknown but might be related to alterations to their passive osmotic properties. We have used two-photon confocal laser scanning microscopy to measure the passive osmotic characteristics of in situ chondrocytes within relatively non-degenerate and degenerate human tibial plateau cartilage, and in chondrocytes isolated from relatively non-degenerate cartilage. Explants with bone attached were taken from a total of 42 patients undergoing arthroplasty and graded macroscopically and microscopically into two groups, grade 0 + 1 and grade 2 + 3. There was a significant increase in cartilage hydration between these two groups (P /=2,500 microm(3)) of that predicted from the decreased interstitial osmotic pressure. These results show that for the majority of cells studied, the differences in passive chondrocyte volume between relatively non-degenerate, degenerate, and isolated cells were entirely accounted for by changes to the extracellular osmolarity (180-515 mOsm).
机译：骨关节炎的特点是许多因素,包括蛋白多糖损失,减少胶原蛋白刚度,提高软骨水化。软骨细胞也会发生肿胀和关联然而,与骨关节炎的程度原因是未知的,但可能是相关的改变被动的渗透特性。我们使用双光子共焦激光扫描显微镜测量被动的渗透现场内的软骨细胞的特征相对不易变质,堕落的人类胫骨平台软骨,软骨细胞分离出相对简软骨。共有42名患者接受关节成形术和分级和宏观上显微镜下分成两组,0 + 1年级2 + 3年级。软骨水化这两个组之间(P / = 2500microm(3))预测的下降间隙渗透压。对于大多数细胞研究被动的软骨细胞体积之间的差异相对简,简并,孤立的细胞被完全占了改变细胞外渗透性(180 - 515年mOsm)。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号