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首页> 外文期刊>Journal of Cellular Physiology >Angiopoietin 1 prevents retinal detachment in an aggressive model of proliferative retinopathy, but has no effect on established neovascularization.
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Angiopoietin 1 prevents retinal detachment in an aggressive model of proliferative retinopathy, but has no effect on established neovascularization.

机译：检验1预防视网膜脱离的积极的增生性视网膜病变模型,但没有影响新生血管形成。

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摘要

Vascular endothelial growth factor (VEGF) plays a central role in vasoproliferative diseases in the retina, however, other gene products modulate its effects. The angiopoietins are particularly important in this regard. Angiopoietin 2 (Ang2) collaborates with VEGF to stimulate neovascularization (NV) in some situations, but in other situations causes regression of NV. Ang2 also causes a transient increase in vascular density during retinal vascular development. In this study, we sought to determine if Ang1 has similar activities. The effects of Ang1 were tested in double transgenic mice with inducible expression of Ang1. Increased expression of Ang1 in the retina during retinal vascular development did not cause a detectable alteration in vascular density. Also, unlike Ang2, increased expression of Ang1 had no effect on established retinal or choroidal NV. However, when Ang1 expression was initiated simultaneously with that of VEGF, it strongly suppressed VEGF-induced NV and prevented retinal detachment. These data indicate that the timing of Ang1 expression is a critical determinate of its effects on VEGF-induced NV in the retina; it effectively blocks the initiation and progression of NV, but cannot reverse established NV or reduce leakage from NV. These data suggest that increased expression of Ang1 may be a good strategy for prophylaxis of retinal NV, but is unlikely to be effective as monotherapy of established NV.
机译：血管内皮生长因子(VEGF)扮演核心作用在vasoproliferative疾病然而,视网膜产品调节其他基因效果。重要的在这方面。与VEGF刺激新血管形成(NV)在某些情况下,但是在其他情况下导致回归NV Ang2。也会造成瞬时增加血管密度在视网膜血管的发展。这项研究中,我们试图确定Ang1类似的活动。测试与诱导双转基因小鼠Ang1的表情。视网膜血管在视网膜的发展没有导致血管检测变更密度。对建立视网膜或Ang1无影响脉络膜的NV。然而,当Ang1表达式与VEGF,同时启动强烈抑制VEGF-induced NV和预防视网膜脱离。Ang1表达式是一个关键的时机对VEGF-induced NV的决定性的影响视网膜;和NV的进展,但不能逆转建立了NV或减少泄漏NV。这些数据表明,增加Ang1的表达式可能是一个好的策略来预防视网膜NV,但不太可能有效建立NV的单一疗法。

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