...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cellular Physiology >Phenotypic changes of p53, HER2, and FAS system in multiple normal tissues surrounding breast cancer.
【24h】

Phenotypic changes of p53, HER2, and FAS system in multiple normal tissues surrounding breast cancer.

机译：表型的变化p53、HER2和FAS系统多个乳房周围正常组织癌症。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To determine whether phenotypic field changes occur in tissues adjacent to carcinoma, we assayed, by immunohistochemistry, the expression of HER-2, p53, Fas, and FasL in 72 breast cancers (BC) and multiple autologous peritumoral tissues (PTTs) sampled up to 5 cm distance and in 44 benign breast tumors (BBTs). About 5% and 3% of the PTTs and 4.5% and 6.8% of BBTs showed alterations in HER2 and p53 expression, respectively. Of interest, gene amplification was observed in 50% of HER2 positive PTTs, but not in any HER2 positive BBTs. Fas, highly expressed in BBTs and downregulated in BC, maintained its expression in PTTs, whereas FasL, usually negative in BBTs, was upregulated in BC as well as in the PTTs closest (1 cm) to the invasive lesion. Our data suggest that FasL could be a potential novel biomarker of transformation, which may identify, along with HER2 and p53, precursor lesions in a genetically altered breast tissue.
机译：确定表型变化癌发生在组织相邻,我们化验,通过免疫组织化学表达her - 2、p53、Fas和FasL 72年乳腺癌(BC)和多个自体瘤旁组织(旅游者来说)取样5厘米的距离,在44岁良性乳腺肿瘤(《)。《显示的旅游者来说,4.5%和6.8%改变在HER2和p53表达,分别。观察到50%的HER2阳性旅游者来说,但不是任何HER2阳性,该剧。《生活在公元前表达下调,其维护表现在旅游者来说,而FasL,通常在《负调节在公元前在最近的旅游者来说(1厘米)的入侵病变。潜在的转换、新颖的生物标志物这可能识别、HER2和p53在转基因乳房前体病变组织。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号