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首页> 外文期刊>Journal of Cellular Physiology >Thermotolerance induced at a mild temperature of 40 degrees C protects cells against heat shock-induced apoptosis.
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Thermotolerance induced at a mild temperature of 40 degrees C protects cells against heat shock-induced apoptosis.

机译：耐热性诱导的温和的温度保护细胞免受热40摄氏度触觉细胞凋亡。

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摘要

Apoptosis constitutes a response of organisms to various physiological or pathological stimuli, and to different stresses. The ability of thermotolerance induced at a mild temperature of 40 degrees C to protect against activation of the apoptotic cascade by heat shock was investigated. When Chinese hamster ovary and human adenocarcinoma cervical cells were pretreated at 40 degrees C for 3 h, they were resistant to subsequent lethal heat shock at 43 degrees C. Induction of thermotolerance at 40 degrees C led to increased expression of heat shock proteins 27, 32, 72, and 90. Heat shock induced apoptotic events at the mitochondrial level, involving a decrease in membrane potential, translocation of Bax to mitochondria, and liberation of cytochrome c into the cytosol. These events were diminished in thermotolerant cells. Heat shock (42-45 degrees C) caused activation of initiator caspase-9 and effector caspases-3, -6, and -7, relative to controls at 37 degrees C. Activation of caspases was decreased in thermotolerant cells. Heat shock caused fragmentation of the caspase substrate, inhibitor of caspase-activated DNase. Fragmentation was diminished in thermotolerant cells. Thermotolerance afforded protection against heat shock-induced nuclear chromatin condensation, but not against necrosis.
机译：凋亡反应构成的有机体各种生理或病理刺激,和不同的压力。耐热性诱导的温和的温度40摄氏度预防的激活研究了热休克的凋亡级联。当中国仓鼠卵巢和人类腺癌宫颈细胞进行预处理40摄氏度3 h,他们抵抗随后致命热休克在43摄氏度。耐热性的感应40摄氏度了增加热休克蛋白的表达27日,32岁,72年和90年。事件在线粒体水平,涉及膜电位下降,易位伯灵顿线粒体,细胞色素的解放c细胞溶质。在耐热的细胞。度)激活剂引起的caspase-9和效应器caspases-3、6和7,相对于控制在37度c激活的还在耐热的减少细胞。半胱天冬酶底物,caspase-activated抑制剂DNase。耐热的细胞。防止热触觉核染色质凝结,但不反对坏死。

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