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首页> 外文期刊>Journal of Cellular Physiology >Curcumin prevents methylglyoxal-induced oxidative stress and apoptosis in mouse embryonic stem cells and blastocysts.
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Curcumin prevents methylglyoxal-induced oxidative stress and apoptosis in mouse embryonic stem cells and blastocysts.

机译：姜黄素可以防止methylglyoxal-induced氧化压力和细胞凋亡在小鼠胚胎干细胞细胞和胚泡。

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摘要

Methylglyoxal (MG) is a reactive dicarbonyl compound endogenously produced mainly from glycolytic intermediates. Elevated MG levels in diabetes patients are believed to contribute to diabetic complications. MG is cytotoxic through induction of apoptosis. Curcumin, the yellow pigment of Curcuma longa, is known to have antioxidant and anti-inflammatory properties. In the present study, we examined the effect of curcumin on apoptotic biochemical events caused by incubation of ESC-B5 cells with MG. Curcumin inhibited the MG-induced DNA fragmentation, caspase-3 activation, cleavage of PARP, mitochondrial cytochrome c release, and JNK activation. Importantly, curcumin also inhibited the MG-stimulated increase of reactive oxygen species (ROS) in these cells. In addition, we demonstrated that curcumin prevented the MG-induced apoptosis of mouse blastocysts isolated from pregnant mice. Moreover, curcumin significantly reduced the MG-mediated impairment of blastocyst development from mouse morulas. The results support the hypothesis that curcumin inhibits MG-induced apoptosis in mouse ESC-B5 cells and blastocysts by blocking ROS formation and subsequent apoptotic biochemical events.
机译：甲基乙二醛(MG)是一个被动的二羰基复合内生生产主要来自糖酵解中间产物。糖尿病患者被认为有助于糖尿病的并发症。诱导细胞凋亡。姜黄色素,是已知的抗氧化和消炎作用。目前的研究中,我们审查的影响姜黄素对凋亡生化事件引起的通过孵化ESC-B5细胞MG。抑制了MG-induced DNA碎片,PARP caspase-3激活,乳沟,线粒体细胞色素c的释放和物激活。活性氧的MG-stimulated增加在这些细胞种类(ROS)。表明,姜黄素阻止了MG-induced小鼠胚泡细胞凋亡与怀孕的老鼠。大大减少了MG-mediated障碍从小鼠的桑椹胚胚泡发育。结果支持假设姜黄素抑制在鼠标ESC-B5 MG-induced细胞凋亡细胞和胚泡通过阻止活性氧的形成和随后的凋亡生化事件。

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