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首页> 外文期刊>Journal of Cellular Physiology >Elevated interleukin-9 receptor expression and response to interleukins-9 and -7 in thymocytes during radiation-induced T-cell lymphomagenesis in B6C3F1 mice.
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Elevated interleukin-9 receptor expression and response to interleukins-9 and -7 in thymocytes during radiation-induced T-cell lymphomagenesis in B6C3F1 mice.

机译：高架interleukin-9受体表达和应对interleukins-9和7在胸腺细胞在辐射诱导t细胞便在B6C3F1老鼠。

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Dysregulation of cytokine receptor expression and responsiveness to cytokines is hypothesized to play an important role in the development and expansion of preneoplastic cells or progression of neoplastic cells during the early and late stages of leukemogenesis. To determine the crucial changes in initiated cells that confer significant growth during the early stage of radiation-induced lymphomagenesis, we examined both the expression of receptors for thymus-derived cytokines and thymocyte response to cytokines before the onset of T cell lymphomas in B6C3F1 mice after split-dose irradiation. After irradiation, thymic T cell subsets underwent delayed regeneration consisting of two phases as determined by receptor expression. The first phase occurred within 1 week post-irradiation and was accompanied by transient expansion of T cell subsets strongly expressing receptor genes for IL-1, IL-2, IL-6, IL-7, IL-15, and TNFalpha. The second phase occurred 12 weeks after irradiation and was characterized by increased expression of IL-9Ralpha. Thymocytes from non-irradiated control mice were unresponsive to IL-9. However, IL-9 acted synergistically with IL-7 and PHA to stimulate the proliferation of irradiated cells during the second post-irradiation phase. Moreover, these cells showed hyper-responsiveness to IL-7 or PHA alone compared to age-matched non-irradiated control thymocytes. These results suggest that the unusual expression of IL-9 receptors and/or increased responsiveness of thymocytes to cytokines are key processes in the development of radiation-induced T cell lymphomas. J. Cell. Physiol. 198: 82-90, 2004.
机译：细胞因子受体表达的失调响应性细胞因子的假设发展和发挥着重要的作用肿瘤出现前的细胞或进展的扩张在早期和晚期的肿瘤细胞的白血病生成阶段。至关重要的启动细胞带来的变化在早期阶段的显著增长辐射诱导便,我们检查了两种受体的表达thymus-derived细胞因子和胸腺细胞反应在T细胞淋巴瘤的发病前细胞因子在B6C3F1 split-dose照射后小鼠。辐照后,胸腺T细胞的子集接受延迟再生两个组成阶段由受体表达。第一阶段发生在1周并伴随着瞬态机理扩张的T细胞亚群强烈表达receptor基因for IL-1 IL-2、IL-6 IL-7 IL-15,和TNFalpha。辐照后的特征增加IL-9Ralpha的表达式。从non-irradiated控制老鼠IL-9反应迟钝。协同IL-7和PHA刺激期间辐照细胞的扩散第二阶段的机理。细胞显示hyper-responsiveness IL-7或PHA孤独与non-irradiated相比胸腺细胞的控制。IL-9受体的异常表达和/或增加胸腺细胞的响应能力细胞因子是发展的关键过程辐射诱导T细胞淋巴瘤。杂志。198:82 - 90年,2004年。

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