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首页> 外文期刊>Journal of Cellular Physiology >Gonadotropin and steroid hormones stimulate proliferation of the rat ovarian surface epithelium.
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Gonadotropin and steroid hormones stimulate proliferation of the rat ovarian surface epithelium.

机译：促性腺激素和类固醇激素刺激大鼠卵巢表面扩散上皮细胞。

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摘要

The ovarian surface epithelium (OSE) is a single layer of flattened or cuboidal cells covering the ovary. Ninety percent of all human ovarian malignancies arise from this layer of cells. Incessant ovulation, hyperovulation induced by infertility treatment, and hormone replacement therapy have been suggested as risk factors for ovarian cancer. In this study, two groups of rats, with and without surgically induced injury to the ovary, were treated with 17beta-estradiol, pregnant mare's serum gonadotropin (PMSG), human chorionic gonadotropin (hCG), or the combination PMSG/hCG, and the proliferative response of the OSE cells was measured using bromodeoxyuridne (BrdU) and (3)H-thymidine. All hormones, alone or in combination with ovarian surgery, were found to increase significantly the rate of proliferation of the rat OSE. These data demonstrate that hormones associated with infertility treatments and hormone replacement therapy, as well as injury- or ovulation-induced rupture of the ovarian surface, stimulate the rat OSE, and hence could have a role in the development of ovarian cancer via proliferation-associated mutagenesis, or alternatively, by promoting the rapid selection of OSE cells with accumulated mutations. J. Cell. Physiol. 198: 119-124, 2004.
机译：卵巢表面上皮(OSE)是一个单身覆盖层扁平或立方形的细胞卵巢。从这层细胞恶性肿瘤出现。不断的排卵,hyperovulation诱导不孕不育治疗和激素替代治疗被认为是危险因素卵巢癌。老鼠,有或没有手术引起的损伤与17个beta雌二醇治疗卵巢,孕马血清促性腺激素(PMSG)人绒毛膜促性腺激素(hCG)或组合PMSG /促性和增生性反应该细胞用bromodeoxyuridne测量(BrdU)和(3)H-thymidine。结合卵巢手术,被发现显著增加的速度河鼠OSE扩散。证明激素有关不孕不育治疗和激素替代治疗,以及损伤或特别破裂的卵巢表面,刺激大鼠大阪证交所,因此可能会有作用卵巢癌的发展通过proliferation-associated诱变,或另外,通过促进快速选择大阪证交所细胞积累的突变。杂志。198:119 - 124年,2004年。

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