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首页> 外文期刊>Journal of Cellular Physiology >8-prenylnaringenin, a novel phytoestrogen, inhibits angiogenesis in vitro and in vivo.
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8-prenylnaringenin, a novel phytoestrogen, inhibits angiogenesis in vitro and in vivo.

机译：8-prenylnaringenin,新奇的植物雌激素,抑制血管生成在体外和体内。

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摘要

8-Prenylnaringenin is a recently discovered phytoestrogen. Using an in vitro model of angiogenesis in which endothelial cells can be induced to invade a three-dimensional collagen gel within which they form capillary-like tubes, we demonstrate that 8-prenylnaringenin inhibits angiogenesis induced by basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), or the synergistic effect of the two cytokines in combination, with an IC(50) of between 3 and 10 microM. This effect was seen with bovine microvascular endothelial cells derived from the adrenal cortex (BME cells) and with endothelial cells from the bovine thoracic aorta (BAE cells). The inhibitory effects of 8-prenylnaringenin were found to be roughly equipotent to those of genistein that has previously been shown to inhibit angiogenesis in vitro. Early chorioallantoic membrane (CAM) assay results showed reductions in both vessel lengths and vein diameters, with similar potency in the 8-prenylnaringenin and genistein groups.Similar effects on the CAM vessels were seen when the two substances were co-added. These findings suggest that 8-prenylnaringenin has potential therapeutic applications for diseases in which angiogenesis is an important component.
机译：8-Prenylnaringenin是最近发现的植物雌激素。血管的内皮细胞诱导入侵三维胶原蛋白凝胶中形成capillary-like管,我们证明8-prenylnaringenin抑制引起的血管生成基本的纤维母细胞生长因子(bFGF)、血管内皮生长因子(VEGF),或两者的协同效应细胞因子结合,IC (50)3至10 microM。牛微血管内皮细胞来源于肾上腺皮质细胞(BME)从牛胸与内皮细胞主动脉(BAE细胞)。8-prenylnaringenin被发现染料木素的均等的之前被证明能够抑制血管生成体外。结果显示减少两船的长度和静脉直径,类似的效力8-prenylnaringenin和染料木黄酮组。影响凸轮船只被认为当两个物质是co-added。8-prenylnaringenin有潜在的治疗应用血管的疾病是一个重要组成部分。

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