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首页> 外文期刊>Journal of Cellular Physiology >Role of cell-cycle regulatory proteins in gynecological cancer.
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Role of cell-cycle regulatory proteins in gynecological cancer.

机译:细胞循环调控蛋白的作用妇科癌症。

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摘要

Human malignant tumors are characterized by abnormal proliferation resulting from alterations in cell-cycle regulatory mechanisms. This review summarizes the current knowledge about these aberrations in malignant tumors of the ovary, endometrium, cervix uteri, and vulva. The data indicate that analysis of single cell cycle stimulating or inhibiting proteins partly produces unexpected, apparently paradoxical results, and cell-cycle regulatory pathways should be regarded as a whole in order to identify the molecular mechanisms leading to abnormal tumor cell proliferation. For the papillomavirus (HPV)- associated cervical and vulvar carcinomas, the manifold effects of the viral oncogenes E6 and E7 on cell-cycle control are described. J. Cell. Physiol. 196: 224-244, 2003.
机译:人类恶性肿瘤的特征导致的异常增殖变化在细胞循环监管机制。总结了当前关于这些知识畸变在卵巢恶性肿瘤,子宫内膜、子宫颈和阴户。表明,单一的细胞周期的分析刺激或抑制蛋白质部分产生意想不到的,显然是矛盾的结果,细胞循环管理途径应该被视为一个整体来识别的分子机制导致异常的肿瘤细胞增殖。乳头瘤病毒(HPV)——宫颈癌和有关外阴癌的多方面的影响病毒致癌基因E6、E7细胞循环控制描述。2003.

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