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首页> 外文期刊>Journal of Cellular Physiology >How the other half lives, the amino-terminal domain of the retinoblastoma tumor suppressor protein.
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How the other half lives, the amino-terminal domain of the retinoblastoma tumor suppressor protein.

机译：另外一半是怎么生活的,伴视网膜母细胞瘤的肿瘤抑制基因蛋白质。

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摘要

The retinoblastoma tumor suppressor gene (RB1) is currently the only known gene whose mutation is necessary and sufficient for the development of a human cancer. Mutation or deregulation of RB1 is observed so frequently in other tumor types that compromising RB1 function may be a prerequisite for malignant transformation. Identifying the molecular mechanisms that provide the basis for RB1-mediated tumor suppression has become an important goal in the quest to understand and treat cancer. The lion's share of research on these mechanisms has focused on the carboxy-terminal half of the RB1 encoded protein (pRB). This focus is with good reason since this part of the protein, now called the "large pocket," is required for most of its known activities identified in vitro and in vivo. Large pocket mediated mechanisms alone, however, cannot account for all observed properties of pRB. The thesis presented here is that the relatively uncharacterized amino-terminal half of the protein makes important contributions to pRB-mediated tumor suppression. The goals of this review are to summarize evidence indicating that an amino-terminal structural domain is important for pRB function and to suggest a general hypothesis as to how this domain can be integrated with current models of pRB function. J. Cell. Physiol. 197: 169-180, 2003Copyright 2003 Wiley-Liss, Inc.
机译：视网膜母细胞瘤的肿瘤抑制基因(RB1)目前唯一已知基因的突变必要和充分的发展人类癌症。如此频繁的观察到在其他肿瘤类型妥协RB1函数可能是一个先决条件对于恶性转变。分子机制提供了依据RB1-mediated肿瘤抑制已成为在寻求理解和重要的目标治疗癌症。这些机制都集中在carboxy-terminal RB1编码蛋白质的一半(复审委员会)。蛋白质的组成部分,现在被称为“大口袋里,“已知的大部分需要活动确定在体外和体内。然而,口袋里独自介导机制不能占所有观察到的复审委员会的性质。这里给出的论文是相对的但一个个伴的一半蛋白质使重要贡献pRB-mediated肿瘤抑制。回顾总结证据表明一个伴结构域是重要的复审委员会的功能和显示一个将军假设这个域可以是如何结合当前复审委员会函数的模型。j .细胞。2003 Wiley-Liss, Inc。

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