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首页> 外文期刊>Journal of Cellular Physiology >Roads to polyploidy: the megakaryocyte example.
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Roads to polyploidy: the megakaryocyte example.

机译：道路多倍体:巨核细胞的例子。

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摘要

Polyploidy, recognized by multiple copies of the haploid chromosome number, has been described in plants, insects, and in mammalian cells such as, the platelet precursors, the megakaryocytes. Several of these cell types reach high ploidy via a different cell cycle. Megakaryocytes undergo an endomitotic cell cycle, which consists of an S phase interrupted by a gap, during which the cells enter mitosis but skip anaphase B and cytokinesis. Here, we review the mechanisms that lead to this cell cycle and to polyploidy in megakaryocytes, while also comparing them to those described for other systems in which high ploidy is achieved. Overall, polyploidy is associated with an orchestrated change in expression of several genes, of which, some may be a result of high ploidy and hence a determinant of a new cell physiology, while others are inducers of polyploidization. Future studies will aim to further explore these two groups of genes.
机译：多倍体,认可的多个副本单倍体染色体数目,已被描述植物、昆虫、哺乳动物细胞等,血小板前兆,巨核细胞。其中一些细胞类型达到高倍数性通过不同的细胞周期。endomitotic细胞周期,由一个年代阶段打断了差距,在此期间细胞进入有丝分裂但跳过后期B和胞质分裂。导致细胞周期和多倍体巨核细胞,同时也比较这些描述高的其他系统倍性。与策划的变化有关几个基因的表达,其中,有些可能是一个高倍数性和因此造成的新的细胞生理学的行列式,而别人是多倍体化的诱导物。这两个研究将致力于进一步探索组织的基因。

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