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首页> 外文期刊>Journal of Cellular Physiology >Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha.
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Obesity modulates the expression of haptoglobin in the white adipose tissue via TNFalpha.

机译：肥胖调节结合珠蛋白的表达通过TNFalpha白色脂肪组织。

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摘要

Increase in adipose mass results in obesity and modulation of several factors in white adipose tissue (WAT). Two important examples are tumor necrosis factor alpha (TNFalpha) and leptin, both of which are upregulated in adipose tissue in obesity. In order to isolate genes differentially expressed in the WAT of genetically obese db/db mice compared to their lean littermates, we performed RNA fingerprinting and identified haptoglobin (Hp), which is significantly upregulated in the obese animals. Hp is a glycoprotein induced by a number of cytokines, LPS (Lipopolysaccharide), and more generally by inflammation. A significant upregulation of WAT Hp expression was also evident in several experimental obese models including the yellow agouti (/) A(y), ob/ob and goldthioglucose-treated mice (10-, 8-, and 7-fold, respectively). To identify the potential signals for an increase in Hp expression in obesity, we examined leptin and TNFalpha in vivo. Wild type animals treated with recombinant leptin did not show any alteration in WAT Hp expression compared to controls that were food restricted to the level of intake of the treated animals. On the other hand, Hp expression was induced in mice transgenically expressing TNFalpha in adipose tissue. Finally, a significant downregulation of WAT Hp mRNA was observed in ob/ob mice deficient in TNFalpha function, when compared to the ob/ob controls. These results demonstrate that haptoglobin expression in WAT is increased in obesity in rodents and TNFalpha is an important signal for this regulation.
机译：增加脂肪会导致肥胖和质量白色脂肪调制的几个因素组织(窟)。坏死因子α(TNFalpha)和瘦素调节脂肪组织中肥胖。窟中表达的基因肥胖db / db老鼠相比,他们的精益的同胞,我们执行RNA指纹识别结合珠蛋白(Hp),这是明显的调节肥胖的动物。糖蛋白引起大量的细胞因子,有限合伙人(脂多糖)和更普遍炎症。惠普在几个表达也明显实验性肥胖模型包括黄色goldthioglucose-treated老鼠(8 - 10 -,分别为7倍)。惠普表达增加的信号肥胖,我们检查了瘦素和TNFalpha体内。野生型动物重组瘦素处理窟惠普表达式没有任何改变而食品限制的控制对待动物的摄入水平。另一方面,惠普表达诱导的小鼠transgenically表达TNFalpha脂肪组织。窟惠普mRNA在ob / ob老鼠缺乏在TNFalpha函数中,相比ob / ob控制。在窟结合珠蛋白表达增加啮齿动物和TNFalpha肥胖是一个重要的信号调节。

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