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首页> 外文期刊>Journal of Cellular Physiology >Molecular biology and immunoregulation of human neurotropic JC virus in CNS.
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Molecular biology and immunoregulation of human neurotropic JC virus in CNS.

机译：分子生物学和免疫调节的人类亲神经的JC病毒在中枢神经系统。

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摘要

The human polyomavirus, JC virus (JCV), provides an excellent model system to investigate the reciprocal interaction of the immune and nervous systems. Infection with JCV occurs during childhood and the virus remains in the latent state with no apparent clinical symptoms. However, under immunosuppressed conditions, the virus enters the lytic cycle and upon cytolytic destruction of glial cells, causes the fatal demyelinating disease of the central nervous system (CNS), named progressive multifocal leukoencephalopathy (PML). In this short review, we discuss the molecular pathogenesis of PML by highlighting the role of the immune system in modulating JCV gene activation and replication, and the latency/reactivation of this virus upon immunosuppression. Further, due to the higher incidence of PML among AIDS patients, we further elaborate on the cross-talk between JCV and HIV-1 by direct and indirect pathways that lead to enhanced expression of the JCV genome.
机译：人类的多瘤病毒,JC病毒(JCV)提供一个优秀的模型系统调查相互交互的免疫和神经系统。童年和病毒仍然在潜伏状态没有明显的临床症状。然而,在免疫抑制条件下,病毒进入裂解周期和细胞溶解的胶质细胞的破坏,导致死亡中枢神经脱髓鞘疾病系统(CNS),名叫渐进多焦点的脑白质病(PML)。我们讨论的分子发病机制PML强调免疫系统的作用调制JCV基因激活和复制,和延迟/复活的病毒免疫抑制。PML的发病率在艾滋病患者中,我们进一步详细说明JCV和hiv - 1之间的串音通过直接和间接途径导致增强了JCV基因组的表达。

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