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首页> 外文期刊>Journal of Cellular Physiology >Physiological functions of imprinted genes.
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Physiological functions of imprinted genes.

机译:印迹基因的生理功能。

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摘要

Genomic imprinting in gametogenesis marks a subset of mammalian genes for parent-of-origin-dependent monoallelic expression in the offspring. Embryological and classical genetic experiments in mice that uncovered the existence of genomic imprinting nearly two decades ago produced abnormalities of growth or behavior, without severe developmental malformations. Since then, the identification and manipulation of individual imprinted genes has continued to suggest that the diverse products of these genes are largely devoted to controlling pre- and post-natal growth, as well as brain function and behavior. Here, we review this evidence, and link our discussion to a website (http://www.otago.ac.nz/IGC) containing a comprehensive database of imprinted genes. Ultimately, these data will answer the long-debated question of whether there is a coherent biological rationale for imprinting.
机译:基因组印记在配子形成标志着一个子集parent-of-origin-dependent哺乳动物的基因monoallelic表达式的后代。胚胎学和经典遗传实验在老鼠身上,发现了基因的存在印迹近二十年前生产的增长或异常行为,没有严重的发育畸形。个人的识别和处理印迹基因继续显示这些基因在很大程度上是不同的产品致力于控制前和产后增长,以及大脑功能和行为。在这里,我们审查这些证据,并联系我们讨论一个网站包含一个(http://www.otago.ac.nz/IGC)全面的印迹基因数据库。最终,这些数据将回答怒江是否有问题连贯的生物印迹的理由。

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