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首页> 外文期刊>Journal of Cellular Physiology >Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodeling.
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Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodeling.

机译：心肌细胞凋亡的病理生理的作用post-infarction左心室重构。

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摘要

Left ventricular (LV) remodeling and heart failure (HF) complicate acute myocardial infarction (AMI) even weeks to months after the initial insult. Apoptosis may represent an important pathophysiologic mechanism causing progressive myocardiocyte loss and LV dilatation even late after AMI. This review will discuss the role of apoptosis according to findings in animal experimental data and observational studies in humans in order to assess clinical relevance, determinants, and mechanisms of myocardial apoptosis and potential therapeutic implications. More complete definition of the impact of myocardiocyte loss on prognosis and of the mechanisms involved may lead to improved understanding of cardiac remodeling and possibly improved patients' care. Mitochondrial damage and bcl-2 to bax balance play a central role in ischemia-dependent apoptosis while angiotensin II and beta(1)-adrenergic-stimulation may be major causes of receptor-mediated apoptosis. Benefits due to treatment with ACE-inhibitors and beta-blockers appear to be in part due to reduced myocardial apoptosis. Moreover, infarct-related artery patency late after AMI may be a major determinant of myocardial apoptosis and clinical benefits deriving from an open artery late post AMI (the "open artery hypothesis") may be, at least in part, due to reduced myocardiocyte loss.
机译：左心室(LV)改造和心脏衰竭(高频)复杂的急性心肌梗死(AMI)甚至数周至数月后最初的侮辱。细胞凋亡可能代表一个重要病理生理机制导致进步myocardiocyte损失和LV扩张甚至迟到在AMI。根据调查结果在动物细胞凋亡实验数据和观察性研究人类为了评估临床意义,决定因素和心肌的机制细胞凋亡和潜在的治疗意义。更完整的定义的影响myocardiocyte的预后和损失机制可能导致改善对心脏重构和可能的理解改善病人的护理。bcl - 2伯灵顿平衡中发挥着关键作用ischemia-dependent凋亡,血管紧张素ⅱ和β(1)-adrenergic-stimulation可能是主要的受体介导细胞凋亡的原因。由于治疗与血管紧张素转换酶抑制剂β受体阻断剂似乎是部分由于减少了心肌细胞凋亡。AMI后动脉开放后期可能是主要的行列式的心肌细胞凋亡和临床好处源于开放动脉晚期AMI(“开放动脉假说”),至少在某种程度上,由于减少myocardiocyte损失。

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