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首页> 外文期刊>Journal of the American Animal Hospital Association >Evaluation of systemic and secretory IgA concentrations and immunohistochemical stains for IgA-containing B cells in mucosal tissues of an Irish setter with selective IgA deficiency
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Evaluation of systemic and secretory IgA concentrations and immunohistochemical stains for IgA-containing B cells in mucosal tissues of an Irish setter with selective IgA deficiency

机译：系统性和分泌IgA的评价浓度和免疫组织化学染色IgA-containing B细胞的粘膜组织爱尔兰setter与选择性IgA缺乏症

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摘要

Immunoglobulin A is the predominant secretory antibody at mucosal surfaces. In the dog, immunoglobulin A deficiency (IgAD) is characterized by low to absent serum IgA and normal to elevated serum immunoglobulin G (IgG) and immunoglobulin M (IgM) concentrations. However, studies comparing serum and secretory IgA in dogs have often documented a poor correlation, suggesting that serum concentrations should not be used to estimate mucosal secretion of this antibody. This report demonstrates the concurrent use of serum IgA, IgG, and IgM; secretory IgA (from bronchoalveolar lavage fluid); and immunohistochemical stains on bronchial and duodenal mucosa for IgA-containing B cells in a young Irish setter with recurrent respiratory and gastrointestinal signs.
机译：免疫球蛋白是主要的分泌在粘膜表面抗体。免疫球蛋白缺乏症(东非)特点是低血清IgA和缺席正常升高血清免疫球蛋白G(免疫球蛋白)和免疫球蛋白M (IgM)浓度。然而,研究比较血清和分泌IgA的狗经常记录一个贫穷相关性,这表明血清浓度不应该用来估计粘膜分泌这种抗体。并发使用血清IgA免疫球蛋白,IgM;分泌IgA(从支气管肺泡灌洗液);支气管和IgA-containing十二指肠粘膜与复发性B细胞在一个年轻的爱尔兰setter呼吸道和胃肠道的迹象。

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