...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cellular Physiology >Cancer and anticancer therapy-induced modifications on metabolism mediated by carnitine system.
【24h】

Cancer and anticancer therapy-induced modifications on metabolism mediated by carnitine system.

机译：癌症和抗癌治疗导致修改肉碱代谢介导系统。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

An efficient regulation of fuel metabolism in response to internal and environmental stimuli is a vital task that requires an intact carnitine system. The carnitine system, comprehensive of carnitine, its derivatives, and proteins involved in its transformation and transport, is indispensable for glucose and lipid metabolism in cells. Two major functions have been identified for the carnitine system: (1) to facilitate entry of long-chain fatty acids into mitochondria for their utilization in energy-generating processes; (2) to facilitate removal from mitochondria of short-chain and medium-chain fatty acids that accumulate as a result of normal and abnormal metabolism. In cancer patients, abnormalities of tumor tissue as well as nontumor tissue metabolism have been observed. Such abnormalities are supposed to contribute to deterioration of clinical status of patients, or might induce cancerogenesis by themselves. The carnitine system appears abnormally expressed both in tumor tissue, in such a way as to greatly reduce fatty acid beta-oxidation, and in nontumor tissue. In this view, the study of the carnitine system represents a tool to understand the molecular basis underlying the metabolism in normal and cancer cells. Some important anticancer drugs contribute to dysfunction of the carnitine system in nontumor tissues, which is reversed by carnitine treatment, without affecting anticancer therapeutic efficacy. In conclusion, a more complex approach to mechanisms that underlie tumor growth, which takes into account the altered metabolic pathways in cancer disease, could represent a challenge for the future of cancer research. Copyright 2000 Wiley-Liss, Inc.
机译：一个有效的监管燃料代谢响应内部和环境刺激一个至关重要的任务,需要一个完整的肉碱系统。肉碱,它的衍生品,和蛋白质参与在其转换和传输,不可或缺的葡萄糖和脂质代谢细胞。肉碱系统:(1)促进条目长链脂肪酸进入线粒体他们利用在发电过程中;(2)促进去除从线粒体短链和碳链脂肪酸正常和异常的积累结果新陈代谢。肿瘤组织以及nontumor组织新陈代谢曾被观察到。应该有助于恶化临床状态的病人,或可能诱发癌发生。系统出现异常表达在肿瘤组织,以这样一种方式大大减少脂肪酸机会,nontumor组织。这种观点,肉碱的研究系统代表一个工具来理解分子基本正常的新陈代谢和基础癌细胞。肉碱系统的功能障碍在nontumor组织,所逆转肉碱治疗,而不影响抗癌治疗效果。复杂的背后机制的方法考虑了肿瘤的生长改变代谢途径在癌症疾病,可能是一个挑战的未来癌症研究。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号