Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration.

Gao Y; Li M; Chen WSimons M

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Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration.

机译：Synectin, syndecan-4胞质域绑定PDZ蛋白质,抑制细胞迁移。

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Syndecan-4, a member of the syndecan gene family of proteoglycans, is an important regulator of bFGF signaling. In particular, bFGF-dependent regulation of cell growth and migration has been linked to syndecan-4 cytoplasmic domain-mediated interactions. Screening of a yeast two-hybrid library with a cytoplasmic domain of rat syndecan-4 identified a novel binding partner, here termed synectin. Synectin is highly homologous to semaphorin F binding protein semcap1, glucose 1 transporter binding protein glut1cbp, and RGS-GAIP/neuropilin-1 binding protein GIPC. Overexpression of synectin in ECV304 cells in culture led to a dose-dependent inhibition of migration while not affecting cell adhesion or growth rate. We conclude that synectin is involved in syndecan-4-dependent interactions and may play a role in the assembly of syndecan-4 signaling complex. Copyright 2000 Wiley-Liss, Inc.

机译：Syndecan-4 syndecan基因家族的一员蛋白聚糖,是一种重要的监管机构bFGF信号。调节细胞生长和迁移与syndecan-4细胞质domain-mediated有关交互。图书馆的胞质域老鼠syndecan-4发现小说约束力的合作伙伴,这里称为synectin。同源semaphorin F结合蛋白semcap1,葡萄糖转运体结合蛋白glut1cbp和RGS-GAIP / neuropilin-1绑定蛋白质GIPC。ECV304细胞文化导致剂量依赖性抑制虽然不影响细胞迁移粘附或增长率。synectin syndecan-4-dependent相互作用,可能在装配中发挥作用syndecan-4信号复杂。Wiley-Liss公司。

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《Journal of Cellular Physiology》 |2000年第3期|373-379|共7页
作者
Gao Y; Li M; Chen WSimons M;
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作者单位

Angiogenesis Research Center, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Cytoplasmic Domain; Cell Growth Regulation; ProteoglycansCarrier ProteinsCell Migrationsyndecan 4Cell LocomotionBinding ProteinPDZ proteinMembrane Glycoproteins;

机译：胞质域;细胞生长监管;ProteoglycansCarrier ProteinsCellMigrationsyndecan 4细胞LocomotionBindingProteinPDZ proteinMembrane Glycoproteins;

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Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration.

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