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首页> 外文期刊>Journal of Cellular Physiology >Retinal and choroidal neovascularization.
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Retinal and choroidal neovascularization.

机译：视网膜和脉络膜新生血管形成。

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The unique vascular supply of the retina, the ability to visualize the vasculature in vivo, and the ability to selectively express genes in the retina make the retina an ideal model system to study molecular mechanisms of angiogenesis. In addition, this area of investigation has great clinical significance, because retinal and choroidal neovascularization are the most common causes of severe visual loss in developed countries and new treatments are needed. As a result, interest in ocular neovascularization is rapidly growing and there has been considerable recent progress. Use of genetically engineered mice in recently developed murine models provides a means to investigate the role of individual gene products in neovascularization in two distinct vascular beds, the retinal vasculature and the choroidal vasculature. It appears that angiogenesis in different vascular beds has common themes, but also has tissue-specific aspects. This review summarizes recent progress in the field of ocular neovascularization and the prospects that it provides for the development of new treatments. Copyright 2000 Wiley-Liss, Inc.
机译：独特的视网膜血管供应,体内血管的可视化能力,选择性地表达基因的能力视网膜使视网膜的理想模式系统研究血管生成的分子机制。此外,这个地区调查的临床意义,因为视网膜和脉络膜新生血管形成是最常见的导致严重的视力丧失在发达国家和新的治疗方法是必要的。因此,兴趣眼部新生血管形成快速增长,已经有相当大的最近的进展。老鼠在鼠模型的最新研究进展一种手段来调查个人的角色基因产物在两个新血管形成不同的血管床,视网膜血管和脉络膜的脉管系统。血管生成在不同的血管床常见的主题,但也有组织方面。眼部新生血管形成和领域它提供了发展的前景新的治疗方法。

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