Differential regulation and expression of stress proteins and ferritin in human monocytes.

Bornman L; Baladi S; Richard MJTyrrell RMPolla BS

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Differential regulation and expression of stress proteins and ferritin in human monocytes.

机译：微分调节和表达的压力蛋白质和铁蛋白在人类单核细胞。

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We investigated the regulation and expression of ferritin in human cells by exposing peripheral blood monocytes (PBM) to heat shock (HS), opsonized sheep red blood cells (RBC), and iron. Iron induced ferritin but had no effect on stress protein expression. HS did not induce ferritin, indicating that ferritin is not a heat shock protein (HSP), at least in human PBM. In contrast, erythrophagocytosis (EP), a model for oxidative stress and endogenous iron release, induced HSP, heme oxygenase (HO), and ferritin. During EP, the antioxidant flavonoid quercetin prevented the induction of ferritin and HO, while it had no effect on the induction of ferritin by iron. In contrast, the iron chelator o-phenanthroline prevented the induction of ferritin during both EP and iron exposure. Differential effects of the transcriptional inhibitor actinomycin D on the various stress proteins revealed transcriptional regulation of HSP and HO during EP, whereas the induction of ferritin was posttranscriptionally regulated. We propose that while ferritin is not an HSP, its induction during EP is mediated through the action of ROS and is promoted by the iron released from RBC. Induction of ferritin and the subsequent iron sequestration may protect PBM from oxidative injury by limiting the iron-catalysed free radical reactions during EP.

机译：我们调查了监管和表达铁蛋白在人类细胞暴露外围血液单核细胞(PBM)热休克(HS),调理的绵羊红细胞(RBC)和铁。铁铁蛋白诱导但没有对应力的影响蛋白表达。表明铁蛋白不是热休克蛋白(HSP),至少在人类PBM。相反,erythrophagocytosis (EP),模型氧化应激和内源性铁释放,诱导HSP,血红素加氧酶(HO)和铁蛋白。在EP,抗氧化剂类黄酮素槲皮素阻止铁蛋白的诱导和HO,它没有影响铁蛋白的诱导铁。o-phenanthroline阻止的感应铁蛋白在EP和铁接触。微分的影响转录抑制剂放线菌素D上的各种压力蛋白质转录调控HSP在EP和HO,而诱导铁蛋白是转录后的监管。提出,虽然铁蛋白物质本身并不是一个,感应在EP是通过介导的活性氧的作用,是提升的铁从红细胞释放。后续铁封存可能保护PBM从氧化损伤通过限制在EP iron-catalysed自由基反应。

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来源
《Journal of Cellular Physiology》 |1999年第1期|1-8|共8页
作者
Bornman L; Baladi S; Richard MJTyrrell RMPolla BS;
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作者单位

Laboratoire de Physiologie Respiratoire, University Paris V, France.;

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正文语种英语
中图分类细胞生物学;
关键词
Iron; Ferritins; chelating agentsMonocytesHeat Shock Proteins;

机译：铁、铁蛋白、螯合agentsMonocytesHeat冲击蛋白质;

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Differential regulation and expression of stress proteins and ferritin in human monocytes.

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