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首页> 外文期刊>Journal of Cellular Physiology >POU family transcription factors in the nervous system.
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POU family transcription factors in the nervous system.

机译：POU家族转录因子在神经系统。

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摘要

The POU (Pit-Oct-Unc) family of transcription factors was originally defined on the basis of a common DNA binding domain in the mammalian factors Pit-1, Oct-1, and Oct-2 as well as the nematode protein Unc-86. Subsequently, a number of other POU family factors have been identified in both vertebrates and invertebrates. Many of these original and subsequently isolated members of the family have been shown to play critical roles in the development and functioning of the nervous system. To exemplify this, studies are described involving the functional characterisation of the Oct-2 factor, one of the original POU factors, and of the Brn-3 factors, which were isolated subsequently and are the mammalian factors most closely related to Unc-86.
机译：砰(Pit-Oct-Unc)转录的家庭因素最初定义的基础上常见的哺乳动物的DNA结合域因素Pit-1, oct - 1, Oct-2以及线虫蛋白unc - 86。其他的POU家庭因素已确定在脊椎动物和无脊椎动物。这些原始随后孤立的成员家庭已经被证明的关键角色的开发和运作神经系统涉及的功能描述Oct-2因素的描述,其中一个普原始因素,Brn-3的因素,随后是孤立的,是吗大多数哺乳动物因素密切相关unc - 86。

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