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首页> 外文期刊>Journal of Cellular Physiology >Up-regulation of alpha2,6 sialylation during myeloid maturation: a potential role in myeloid cell release from the bone marrow.
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Up-regulation of alpha2,6 sialylation during myeloid maturation: a potential role in myeloid cell release from the bone marrow.

机译：老年病的alpha2 6 sialylation期间在骨髓髓系成熟:一个潜在的作用细胞从骨髓中释放。

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摘要

The mechanisms by which mature myeloid cells are released from the bone marrow into the peripheral blood are not clearly understood. Glycosylation is likely to play an important role, as has been shown in the homing of lymphocytes to lymph nodes and of neutrophils to inflamed endothelia. Cell surface sialylation is an important component of many cellular adhesive interactions, both as ligand-promoting interactions, as occurs in selectin and sialoadhesin-mediated adhesion, and for reducing cell adhesion as in some cancer cells. We have studied the expression of cell surface alpha2,6-linked sialic acid in the maturation of normal bone marrow myeloid cells, the expression of alpha2,6-sialyltransferase mRNA, and the role of sialylation in the adherence of myeloid cells to bone marrow stroma. Our data show that there is a dramatic increase in cell surface alpha2,6-sialylation during the late stage of maturation. This up-regulation is restricted to specific glycoproteins including CD11b and CD18. It is associated with a relative increase in the level of alpha2,6-sialyltransferase mRNA compared with alpha2,3-sialyltransferase mRNA. The changes in mature bone marrow myeloid cells are associated with reduced cell binding to fibronectin and cultured bone marrow stroma. Our data strongly suggest that alpha2,6-sialylation may be important in the interaction between maturing myeloid cells and bone marrow stroma and may govern the release of cells from the bone marrow into the peripheral blood.
机译：成熟的骨髓细胞的机制从骨髓中释放到周边血并不清楚。可能起着重要的作用,已所示淋巴细胞归巢的淋巴结和中性粒细胞endothelia发炎。表面sialylation是一个重要的组成部分许多细胞粘附互动,既是ligand-promoting交互,如发生在selectin sialoadhesin-mediated粘连,为减少细胞粘附在某些癌症细胞。表面alpha2 6-linked唾液酸成熟的正常骨髓髓系细胞,6-sialyltransferase alpha2的表达信使rna, sialylation的角色依从性髓细胞骨髓基质。我们的数据表明,有一个戏剧性的增加在细胞表面alpha2 6-sialylation期间后期的成熟。局限于特定的糖蛋白等CD11b CD18。增加的程度alpha2 6-sialyltransferase mRNA相比alpha2 3-sialyltransferase信使rna。成熟骨髓髓系细胞有关减少细胞纤连蛋白和有约束力培养骨髓基质。表明alpha2 6-sialylation可能重要的成熟之间的互动髓细胞和骨髓基质和可能管理从骨髓细胞的释放进入外周血。

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