Protein tyrosine phosphatases as negative regulators of mitogenic signaling.

Chernoff J

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Protein tyrosine phosphatases as negative regulators of mitogenic signaling.

机译：蛋白质酪氨酸磷酸酶是负面的监管机构的促有丝分裂的信号。

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The regulation of tyrosine phosphorylation represents a key mechanism governing cell proliferation. In fibroblasts, inputs from both growth factor and extracellular matrix receptors are required for cell division. Triggering such receptors induces a wave of tyrosine phosphorylation on key signaling molecules, culminating in the activation of cyclin-dependent kinases and cell cycle progression. In general, protein tyrosine kinases stimulate, while protein tyrosine phosphatases inhibit, such cell proliferation pathways. The role of protein tyrosine kinases in mitogenesis has been extensively studied, but the identity and targets of the protein tyrosine phosphatases that regulate cell growth are not well described. In this review, I will survey recent advances in the identification and regulation of protein tyrosine phosphatases that downregulate cell proliferation.

机译：酪氨酸磷酸化的监管代表了一个关键的细胞机制管理扩散。生长因子和细胞外基质受体所需的细胞分裂。受体引起一波又一波的酪氨酸磷酸化对关键信号分子,在细胞的激活激酶和细胞周期进程。蛋白质酪氨酸激酶刺激,而蛋白质酪氨酸磷酸酶抑制,这样的细胞扩散途径。在有丝分裂发生酪氨酸激酶进行了广泛的研究,但身份和目标蛋白酪氨酸磷酸酶调节细胞生长不佳。这篇评论,我将调查的最新进展识别和调节蛋白质酪氨酸磷酸酶表达下调细胞扩散。

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来源
《Journal of Cellular Physiology》 |1999年第2期|173-181|共9页
作者
Chernoff J;
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作者单位

Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA. J_Chernoff@fccc.edu;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Signal Transduction; Mitogen; Protein Tyrosine PhosphatasesCyclin-Dependent KinasesCell Proliferationextracellular matrix receptorProtein-Tyrosine KinasesTyrosine PhosphorylationStimulation of Cell Proliferation;

机译：信号转导;有丝分裂原蛋白酪氨酸PhosphatasesCyclin-Dependent KinasesCellProliferationextracellular矩阵PhosphorylationStimulation细胞增殖的;

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Protein tyrosine phosphatases as negative regulators of mitogenic signaling.

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