Hepatocyte growth factor/scatter factor decreases the expression of occludin and transendothelial resistance (TER) and increases paracellular permeability in human vascular endothelial cells.

Jiang WG; Martin TA; Matsumoto KNakamura TMansel RE

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Hepatocyte growth factor/scatter factor decreases the expression of occludin and transendothelial resistance (TER) and increases paracellular permeability in human vascular endothelial cells.

机译：肝细胞生长因子/散射系数降低occludin的表达和transendothelial电阻(TER)和增加paracellular渗透在人类血管内皮细胞。

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Hepatocyte growth factor/scatter factor (HGF/SF), a multi function cytokine has been shown to regulate the expression of cell adhesion molecules in endothelial cells. In the current study, we examined the effects of HGF/SF on the function of tight junctions and the expression of occludin in these cells. Stimulation of human vascular endothelial cells with HGF/SF resulted in a concentration dependent increase in the paracellular permeability as measured using fluorescence labelled dextran but a decrease in the transendothelial cell resistance (TER) of the endothelial cells. Western blotting revealed that HGF/SF decreased the level of occludin in the cells, a primary tight junction forming protein. Immunofluorescence study indicated that shortly after treatment with HGF/SF there was a disturbance of the distribution of occludin and then a reduction in the staining of the molecule. It is concluded that HGF/SF decreases the expression of occludin, resulting in the functional change of tight junction. Copyright 1999 Wiley-Liss, Inc.

机译：肝细胞生长因子/散射因子(HGF / SF),一种多功能细胞因子已被证明调节细胞粘附的表达在内皮细胞分子。研究中,我们调查了HGF / SF的影响紧密连接的函数的表达式occludin在这些细胞。血管内皮细胞与HGF / SF在一个浓度增加的依赖paracellular渗透率测量使用荧光标记右旋糖酐但下降transendothelial细胞抵抗(TER)内皮细胞。HGF / SF occludin的水平在下降细胞,主要紧密连接形成蛋白质。免疫荧光研究表明不久治疗后与HGF / SF有occludin的分布和干扰然后减少的染色分子。得出HGF / SF减少occludin的表达,导致了紧密连接的功能变化。1999 Wiley-Liss, Inc。

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来源
《Journal of Cellular Physiology》 |1999年第2期|319-329|共11页
作者
Jiang WG; Martin TA; Matsumoto KNakamura TMansel RE;
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作者单位

Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Cardiff, United Kingdom. jiangw@cf.ac.uk;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Hepatocytes; Cell Membrane Permeability; Gene Expression RegulationVascular Endothelial CellsEndotheliumCell Adhesion MoleculesOccludinTight Junctions;

机译：肝细胞,细胞膜渗透率;基因表达RegulationVascular内皮MoleculesOccludinTight连接;

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Hepatocyte growth factor/scatter factor decreases the expression of occludin and transendothelial resistance (TER) and increases paracellular permeability in human vascular endothelial cells.

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