C-terminal fragment of parathyroid hormone-related protein, PTHrP-(107-111), stimulates membrane-associated protein kinase C activity and modulates the proliferation of human and murine skin keratinocytes.

Whitfield JF; Isaacs RJ; Jouishomme HMacLean SChakravarthy BRMorley PBarisoni DRegalia EArmato U

首页> 外文期刊>Journal of Cellular Physiology >C-terminal fragment of parathyroid hormone-related protein, PTHrP-(107-111), stimulates membrane-associated protein kinase C activity and modulates the proliferation of human and murine skin keratinocytes.

【24h】

C-terminal fragment of parathyroid hormone-related protein, PTHrP-(107-111), stimulates membrane-associated protein kinase C activity and modulates the proliferation of human and murine skin keratinocytes.

机译：甲状旁腺与荷尔蒙相关的c端片段蛋白质,PTHrP -(107 - 111),刺激膜相关蛋白激酶C活性和调节人类和小鼠的扩散皮肤角化细胞。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Low concentrations of the C-terminal parathyroid hormone-related protein (PTHrP) fragments, PTHrP-(107-111) and PTHrP-(107-139), stimulated membrane-associated protein kinase Cs (PKCs), but not adenylyl cyclase or an internal Ca2+ surge, in early passage human skin keratinocytes and BALB/MK-2 murine skin keratinocytes. The fragment maximally stimulated membrane-associated PKCs in BALB/MK-2 cells at 5 x 10(-9) to 10(-8) M. The maximally PKC-stimulating concentrations of PTHrP-(107-111) also stopped or stimulated BALB/MK-2 keratinocyte proliferation depending on whether the cells were, respectively, cycling or quiescent at the time of exposure. Thus, just one brief (30-minute) pulse of 10(-8) M PTHrP-(107-111) stopped the proliferation of BALB/MK-2 keratinocytes for at least 5 days. On the other hand, daily 30-minute pulses of 10(-8) M PTHrP-(107-111) started and then maintained the proliferation of initially quiescent BALB/MK-2 cells. Similarly PTHrP-(107-111) inhibited DNA synthesis by cycling primary adult human keratinocytes, but it stimulated DNA synthesis by quiescent human keratinocytes.

机译：低浓度的c端甲状旁腺与荷尔蒙相关的蛋白(PTHrP)片段,PTHrP -(107 - 111)和PTHrP -(107 - 139),刺激膜相关蛋白激酶c (PKCs),但是腺苷酸环化酶或内部Ca2 +激增,在人类皮肤角化细胞和早期通道BALB / mk 2小鼠皮肤角化细胞。最大限度地刺激膜相关PKCsBALB / mk 2细胞5 x 10(9)到10 (8)m最大限度PKC-stimulating浓度的PTHrP -(107 - 111)也停止或刺激根据BALB / mk 2角化细胞扩散细胞是否分别骑自行车或静止时的风险。短暂的10(8)(30分钟)脉冲MPTHrP -(107 - 111)停止扩散BALB / mk 2角化细胞至少5天。另一方面,每日30分钟的脉冲10 (8)M PTHrP -(107 - 111)开始,然后维护最初扩散静止BALB / mk 2细胞。合成的自行车主要的成年人角化细胞,但它刺激DNA合成人类角质细胞静止。

著录项

来源
《Journal of Cellular Physiology》 |1996年第1期|1-11|共11页
作者
Whitfield JF; Isaacs RJ; Jouishomme HMacLean SChakravarthy BRMorley PBarisoni DRegalia EArmato U;
展开▼
作者单位

Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada.;

ost.queensu.ca;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
Adenylyl Cyclases; Parathyroid Hormone; DNA synthesisKeratinocytesProtein Kinase CCarboxy-Terminal Amino AcidCell ProliferationParathyroid Hormone-Related Protein;

机译：腺苷酸环化酶;甲状旁腺激素;DNACCarboxy-Terminal氨基AcidCellProliferationParathyroid与荷尔蒙相关的蛋白质;

相似文献

外文文献
中文文献

C-terminal fragment of parathyroid hormone-related protein, PTHrP-(107-111), stimulates membrane-associated protein kinase C activity and modulates the proliferation of human and murine skin keratinocytes.

摘要

著录项

相似文献

相关主题

期刊订阅