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首页> 外文期刊>Journal of Cellular Physiology >Cellular changes during cold acclimatation in adipose tissues.
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Cellular changes during cold acclimatation in adipose tissues.

机译：在寒冷的气候适应细胞变化脂肪组织。

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摘要

Cold exposure is a well-known physiological stimulus that activates the sympathetic nervous system and induces brown adipose tissue (BAT) hyperplasia. The effects of cold exposure or cold acclimatation have been extensively studied in interscapular BAT (IBAT). However, it has been recently shown that studied adipocytes are present in adipose deposits considered as white fat such as periovarian (PO) fat pad. We have investigated the kinetic of brown precursor recruitment in adipose tissues using DNA measurement and specific marker expression. In IBAT, cold exposure induces proliferation of precursor cells and differentiation into preadipocytes characterized by the expression of A2COL6, a marker specific to early steps of the differentiation process. A chronic stimulation of the tissue is necessary to observe the full effect. In PO fat pad, no proliferation can be detected, whereas differentiation of brown preadipocytes and maybe phenotypic conversion of white adipocytes seems to be promoted. In conclusion, these data demonstrated that 1) the same stimulus (cold exposure) does not induce the same response in terms of preadipocyte proliferation and differentiation in periovarian and brown adipose tissues, although both contain brown adipocytes, and 2) preadipocyte recruitment in adipose tissues after cold exposure depends on the predominant type of fat cells.
机译：寒冷暴露是一个著名的生理激活交感神经的刺激系统和诱发褐色脂肪组织(蝙蝠)增生。气候适应被广泛研究肩胛间的蝙蝠(IBAT)。最近研究表明,脂肪细胞出现在脂肪存款认为是白色的脂肪如periovarian (PO)脂肪垫。调查了棕色前体的动能招聘使用DNA在脂肪组织中测量和特定标记表达式。IBAT,寒冷暴露诱导扩散前体细胞分化preadipocytes的表达的特征A2COL6标记特定的早期步骤分化的过程。组织观察完全是必要的的效果。检测到,而分化的棕色preadipocytes也许表型转化白色脂肪细胞似乎被提升。结论,这些数据表明,1)相同的刺激(寒冷暴露)不诱导相同反应preadipocyte在periovarian增殖和分化和褐色脂肪组织,尽管都包含棕色脂肪细胞,2)preadipocyte招聘在寒冷暴露取决于在脂肪组织中主要类型的脂肪细胞。

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