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首页> 外文期刊>Journal of Cellular Physiology >Regulation of human dermal papilla cell production of insulin-like growth factor binding protein-3 by retinoic acid, glucocorticoids, and insulin-like growth factor-1.
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Regulation of human dermal papilla cell production of insulin-like growth factor binding protein-3 by retinoic acid, glucocorticoids, and insulin-like growth factor-1.

机译：人类真皮乳头细胞生产的监管胰岛素样生长因子结合蛋白质3由视黄酸、糖皮质激素和胰岛素样生长因子- 1。

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Insulin-like growth factor-1 (IGF1) has been reported to stimulate hair elongation and to facilitate maintenance of the hair follicle in anagen phase. However, little is known about IGF1 signaling in the hair follicle. In this study we investigate the effects of IGF1, glucocorticoids, and retinoids on dermal papilla (DP) cell production of insulin-like growth factor binding proteins (IGFBPs). IGFBPs comprise a family of IGF binding proteins that are produced and released by most cell types. They bind to IGFs to either enhance or inhibit IGF activity. In the present report we identify IGFBP-3 as being produced and released by cultured human dermal papilla (DP) cells. IGFBP-3 levels are increased fivefold by retinoic acid, eightfold by dexamethasone, and tenfold by IGF1. DP cells are known to produce IGF1, and so the observed stimulation of DP cell IGFBP-3 production by IGF1 is consistent with the idea that DP cells possess the IGF transmembrane receptor kinase and are autoregulated by IGFs. The level ofanother IGFBP, tentatively identified as IGFBP-2, is, in contrast, not regulated by these agents. IGFBP-3 has been shown to inhibit the activity of IGFs in a variety of systems. Our results are consistent with a model in which retinoids and glucocorticoids inhibit IGF action on DP cells and surrounding matrix cells by stimulating increased DP cell production of IGFBP-3. The IGFBP-3, in turn, forms a complex with free IGF1 to reduce the concentration of IGF1 available to stimulate hair elongation and maintenance of anagen phase.
机译：胰岛素样生长因子- 1 (IGF1)刺激头发伸长和报道促进毛囊的维护毛发生长初期阶段。毛囊的信号。调查IGF1的影响、糖皮质激素、类维生素a和真皮乳头细胞(DP)胰岛素样生长因子结合的生产蛋白质(IGFBPs)。生产和IGF结合蛋白发布的大多数细胞类型。增强或抑制IGF活动。现在我们确定IGFBP-3是报告人工培养的真皮生产和发布的乳头(DP)细胞。由视黄酸五倍,8倍地塞米松,IGF1十倍。已知生产IGF1,因此观察到的DP的刺激细胞通过IGF1 IGFBP-3生产是一致的想法,DP细胞拥有互联网管理论坛跨膜受体激酶autoregulated igf。初步确定为IGFBP-2,相反,不受这些代理。已表现出抑制igf的活动各种各样的系统。一个模型类维生素a和糖皮质激素抑制IGF行动DP细胞和周围的基质细胞通过刺激增加IGFBP-3的DP细胞生产。反过来,IGFBP-3形式复杂的自由IGF1减少可用IGF1的浓度刺激头发的伸长和维护毛发生长初期阶段。

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