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首页> 外文期刊>Journal of Cellular Physiology >Okadaic acid Co-induces vimentin expression and cell cycle arrest in MPC-11 mouse plasmacytoma cells.
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Okadaic acid Co-induces vimentin expression and cell cycle arrest in MPC-11 mouse plasmacytoma cells.

机译：冈田酸Co-induces波形蛋白的表达浆细胞瘤细胞周期阻滞在MPC-11老鼠细胞。

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摘要

The effect of the tumor promoter okadaic acid on cell cycle progression and on vimentin expression in MPC-11 mouse plasmacytoma cells was compared with that of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Cell cycle progression of asynchronously grown MPC-11 cells was inhibited by both agents, but, in contrast to the G1 phase arrest caused by TPA, okadaic acid gave rise to G2/M phase and S phase arrest. This effect of okadaic acid was delayed significantly compared to the TPA-caused arrest. Furthermore, okadaic acid was able to induce vimentin expression to an extent comparable to the TPA response. However, vimentin expression was markedly delayed in okadaic acid-treated relative to TPA-treated cells. Another protein phosphatase inhibitor, calyculin A, also induced cell cycle changes and vimentin expression at concentrations at or above 1 x 10(-9) M. Based on these observations, we suggest an involvement of protein phosphatase 1 (possibly also phosphatase 2A and/or other phosphatases)in both the G2/M cell cycle block and the induction of vimentin expression in MPC-11 cells by okadaic acid.
机译：肿瘤的效应启动子冈田酸细胞周期进程和波形蛋白的表达在老鼠MPC-11浆细胞瘤细胞进行比较与肿瘤的启动子12-O-tetradecanoylphorbol-13-acetate (TPA)。周期的异步MPC-11增长细胞抑制由代理商,但是,在造成的G1期逮捕TPA相比,冈田酸了G2 / M期,S期逮捕。明显比TPA-caused被捕。此外,冈田酸能诱导波形蛋白的表达在一定程度上类似TPA反应。是在冈田酸洗明显推迟吗相对于TPA-treated细胞。磷酸酶抑制剂,calyculin,也诱导细胞周期变化和波形蛋白的表达浓度达到或超过1 x 10 m .基于(9)这些观察结果,我们建议的参与蛋白磷酸酶1(也可能磷酸酶2和/或其他磷酸酶)在G2 / M细胞周期阻断和波形蛋白的诱导冈田酸MPC-11细胞中表达。

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