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首页> 外文期刊>Journal of Cellular Physiology >Secretion of plasminogen activator and lysosomal enzymes from mouse skeletal muscle: effect of denervation.
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Secretion of plasminogen activator and lysosomal enzymes from mouse skeletal muscle: effect of denervation.

机译：分泌的纤溶酶原激活物和溶酶体酶从小鼠骨骼肌的效果去神经。

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摘要

Levels of hydrolytic enzymes increase in skeletal muscle after denervation and their activities in the extracellular matrix appear to be important for interaction between muscle and nerve. Using enzymatic assays for beta-glucuronidase, beta-galactosidase, and plasminogen activator, we show that secretion of these enzymes from mouse skeletal muscle increases after denervation and that drugs interfering with the secretory pathway or the reuptake of enzymes modulate this release. Thus, brefeldin A inhibited secretion of plasminogen activator activity and mannan increased secreted amounts of beta-glucuronidase, but not of beta-galactosidase, in denervated muscle. In innervated muscle, brefeldin A decreased secreted activity of plasminogen activator, but mannan had no effect on secretion of either beta-glucuronidase or beta-galactosidase. Furthermore, secretion of plasminogen activator was temperature dependent. These observations, together with previous studies, suggest that secretion of hydrolytic enzymesfrom adult skeletal muscle may be of physiological significance in nerve-muscle communication.
机译：水解酶水平增加骨骼去神经后肌肉和他们的活动细胞外基质似乎是重要的肌肉和神经之间的相互作用。beta-glucuronidase酶化验,苷酶和纤溶酶原激活物,我们从鼠标显示,这些酶的分泌在去神经和骨骼肌增加药物干扰分泌途径或酶调节这个版本的再摄取。因此,brefeldin抑制分泌纤溶酶原激活物活性和甘露聚糖beta-glucuronidase分泌量增加,但不是苷,在去神经的肌肉。减少分泌活动的纤溶酶原。物激活,但甘露聚糖对分泌没有影响beta-glucuronidase或苷酶。纤溶酶原激活物是依赖于温度的。这些观察,连同之前的研究表明,分泌的水解enzymesfrom成人骨骼肌的可能在肌肉紧张的生理意义沟通。

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