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首页> 外文期刊>Journal of Cellular Physiology >Lithium-stimulated proliferation and alteration of phosphoinositide metabolites in MCF-7 human breast cancer cells.
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Lithium-stimulated proliferation and alteration of phosphoinositide metabolites in MCF-7 human breast cancer cells.

机译：Lithium-stimulated核扩散和改变的磷酸肌醇代谢产物在MCF-7人类乳腺癌细胞。

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摘要

Lithium, which is used to treat bipolar psychiatric disorders, can stimulate proliferation of a number of cells in tissue culture. Proliferation of MCF-7 human breast cancer cells, which also respond to EGF and estrogens, was stimulated by LiCl (1-5 mM) within the concentration range that is encountered during human therapy with lithium. Stimulation of growth was specific for lithium; rubidium, potassium, and sodium showed no such effect. In the presence of antiestrogen, lithium stimulated the growth of hormone-dependent breast cancer cells MCF-7, ZR-75-1, and T47D but not hormone-independent MDA-MB-231 cells or an estrogen-independent clone of MCF-7 cells. Lithium-stimulated proliferation was limited by cytotoxicity which could be moderated by added potassium chloride (5-20 mM) in the medium. Each of the mitogens lithium, 17 beta-estradiol, and EGF increased the rate of uptake of myo-inositol into MCF-7 cells. Whether normalized to inositol lipids, to protein, or to DNA, steady-state levels of inositol phosphates were elevated by each of the mitogens including lithium, which inhibits the breakdown of inositol phosphates in the phosphoinositide signaling pathway. These data indicate that therapeutic concentrations of lithium can stimulate the proliferation of human breast cancer cells by a mechanism that may involve the phosphoinositide pathway.
机译：锂,用于治疗双相情感障碍精神疾病,可以刺激增殖的细胞组织文化。癌细胞,也应对EGF和雌激素,刺激了氯化锂(1 - 5毫米)遇到的浓度范围在人类与锂治疗。增长是特定的锂;钾,钠则没有表现出这样的效果。抗雌激素的存在,锂刺激激素依赖性乳癌的增长细胞MCF-7、zr - 75 - 1和T47D但不是或者一个hormone-independent mda - mb - 231细胞estrogen-independent MCF-7细胞的克隆。Lithium-stimulated扩散是有限的细胞毒性可由补充道氯化钾(5 - 20毫米)的媒介。有丝分裂原的锂,17 beta雌二醇,表皮生长因子提高了肌醇的吸收速度成MCF-7细胞。脂质、蛋白质或DNA,稳态肌醇磷酸盐水平升高了每个有丝分裂原,包括锂抑制肌醇磷酸盐的崩溃磷酸肌醇信号通路。数据显示,治疗浓度锂可以刺激人类的扩散乳腺癌细胞的机制涉及磷酸肌醇通路。

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