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首页> 外文期刊>Journal of Cellular Physiology >Transforming growth factor beta modulates growth and differentiation of fetal hepatocytes in primary culture.
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Transforming growth factor beta modulates growth and differentiation of fetal hepatocytes in primary culture.

机译：转化生长因子β调节经济增长和胎儿肝细胞的分化主要的文化。

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摘要

Fetal hepatocytes in primary culture are cells capable to carry out both proliferation and differentiation processes simultaneously. Previous studies have shown that these cells respond to mitogens, such as hepatocyte growth factor (HGF) or epidermal growth factor (EGF), inducing the expression of early genes, such as fos and myc. The transforming growth factor-beta (TGF-beta) family is one of the most influential groups of growth and differentiation factors. In this report, we show that TGF-beta 1 inhibits fetal hepatocyte proliferation, arresting these cells at G1 phase of the cell cycle. In addition, TGF-beta down-regulates the mitogen-induced myc early expression. However, TGF-beta has no effect on the expression of other protooncogenes, such as fos and H-ras. In addition to its inhibitory role on fetal hepatocyte growth, TGF-beta increases the mRNA levels of fibronectin, an extracellular matrix protein, and maintains the expression of some liver specific genes, such as albumin and alfafetoprotein,above control values. The analysis of the expression of some hepatocyte transcriptional factors has shown that TGF-beta increases HNF1 alpha and HNF1 beta mRNA levels. We conclude that TGF-beta may modulate liver growth and differentiation throughout fetal development.
机译：胎儿肝细胞在初代培养细胞进行扩散和能力同时分化过程。先前的研究已经表明,这些细胞对有丝分裂原,如肝细胞生长因子(HGF)和表皮生长因子(EGF),诱导早期基因的表达,如安全系数和myc。(及)家庭是最具影响力的人物之一组织的生长和分化的因素。这个报告中,我们表明,及1抑制胎儿肝细胞增殖,逮捕细胞在细胞周期G1期。鉴定及下调mitogen-induced myc早期的表达式。等其他protooncogenes的表达安全系数和h。胎儿肝细胞生长的作用,及护纤连蛋白的增加mRNA水平细胞外基质蛋白,和维护一些肝脏特定基因的表达,如白蛋白和alfafetoprotein上面控制的价值观。分析一些肝细胞的表达转录因子表明及护增加HNF1α和βHNF1 mRNA水平。我们得出结论,及调节肝脏在胎儿生长和分化发展。

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