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首页> 外文期刊>Journal of Cellular Physiology >Differential regulation of the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and pyruvate kinase by cyclic adenosine 3',5'-monophosphate in fetal and adult hepatocytes.
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Differential regulation of the expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and pyruvate kinase by cyclic adenosine 3',5'-monophosphate in fetal and adult hepatocytes.

机译：微分调节6-pho的表达

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摘要

Incubation of fetal hepatocytes from 21-day-old rats with permeant derivatives of cyclic AMP (cAMP) or glucagon, increased the mRNA levels of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK-2/FBPase-2), L-pyruvate kinase (L-PK) and phosphoenolpyruvate carboxykinase (PEPCK). Contrary to this behavior, adult hepatocytes exhibited a decrease in the PFK-2/FBPase-2 and L-PK mRNA levels when incubated under equivalent experimental conditions. Dexamethasone also increased the PFK-2/FBPase-2 mRNA levels and costimulation of fetal hepatocytes with dexamethasone and a permeant analogue of cyclic AMP enhanced the levels of PFK-2/FBPase-2 mRNA, a situation opposite to that exhibited by adult hepatocytes. Treatment of the hepatocytes with transcriptional and translational inhibitors also produced differential responses in both types of cells. The PFK-2/FBPase-2 mRNA in fetal hepatocytes was more stable than in the adult cells. These results suggest that specific transcriptional factors and regulatory pathways differentially operate in fetal and adult hepatocytes in the control of the responses of carbohydrate metabolism to cAMP.
机译：从21-day-old孵化的胚胎肝细胞环腺苷酸的老鼠与渗透的衍生品(营)或胰高血糖素,增加的mRNA水平2, 6-bisphosphatase (PFK-2 / FBPase-2), L-pyruvate激酶(L-PK)和磷酸烯醇丙酮酸carboxykinase (PEPCK)。成人肝细胞表现出下降PFK-2 / FBPase-2和L-PK mRNA水平时孵化下等效实验条件。PFK-2 / FBPase-2 mRNA水平和聚集有关胎肝细胞和地塞米松环腺苷酸提高了渗透的模拟PFK-2 / FBPase-2 mRNA的水平情况相反,表现出成人肝细胞。治疗肝细胞的转录和转化抑制剂也产生微分反应在两种类型的细胞。PFK-2 / FBPase-2 mRNA在胎儿肝细胞比成人更稳定的细胞。结果表明,特定的转录因素和监管途径不同在胎儿和成人的肝细胞控制碳水化合物的反应新陈代谢营地。

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