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首页> 外文期刊>Human fertility: journal of the British Fertility Society >Could the addition of hp-hMG and GnRH antagonists modulate the response in IVF-ICSI cycles?
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Could the addition of hp-hMG and GnRH antagonists modulate the response in IVF-ICSI cycles?

机译：可以添加hp-hMG GnRH拮抗剂在IVF-ICSI周期调制响应?

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OBJECTIVE: To assess if the luteinizing hormone/human chorionic gonadotropin present in some gonadotropin formulations may be of benefit in protocols with GnRH antagonists. METHODS: Open, quasi-experimental, multicenter, prospective, parallel-controlled study compared 136 women undergoing in vitro fertilization--intracytoplasmic sperm injection after stimulation with highly purified human menopausal gonadotropin (hp-hMG) (n = 44), recombinant-follicle stimulating hormone (r-FSH) (n = 46), or a combination of both (r FSH + hp-hMG) (n = 46) following an antagonist protocol. Blood determinations were made on day 6 of stimulation and on the day of ovulation induction, with centralized analysis. RESULTS: No differences were found in the ongoing pregnancy rates between groups [37.0% versus 29.5% (hp-hMG) and 23.9% (r-FSH); p = 0.688]. However, the ratio top-quality embryos/retrieved oocytes (TQE/RO) was higher in the combined therapy group (19.6%)--reaching significance versus the r-FSH group (6.5%) (p = 0.008), but not versus hp-hMG (12.3%) (p = 0.137). CONCLUSIONS: An improved TQE/RO ratio was obtained together with a greater percentage of frozen embryos in the patients that incorporated hp-hMG to their stimulation protocol. Despite good results of adding hp-hMG, non statistical differences were found in terms of ongoing pregnancy rate.
机译：目的:评估如果黄体化人类绒毛膜促性腺激素在激素/一些促性腺激素配方可能的受益在协议与GnRH拮抗剂。开放、准实验,多中心,未来,parallel-controlled研究比较136名妇女接受体外受精,即卵胞浆内单精子注射与高纯度刺激后人类更年期促性腺激素(hp-hMG) (n = 44),recombinant-follicle刺激激素(r-FSH)(n = 46),或两者的结合(r FSH +hp-hMG) (n = 46)拮抗剂协议。刺激排卵的日子感应,集中分析。差异被发现怀孕的团体之间的利率(37.0%比29.5% (hp-hMG)和23.9% (r-FSH);优质胚胎/检索卵母细胞(TQE / RO)联合治疗组更高(19.6%),达到与r-FSH意义组(6.5%)(p = 0.008),但不是与hp-hMG(12.3%) (p = 0.137)。TQE / RO一起获得了更大的比例冷冻胚胎的患者百分比合并hp-hMG刺激协议。非统计方面的差异被发现正在进行的怀孕率。

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