Electrotaxis of lung cancer cells in a multiple-electric-field chip

Huang CW; Cheng JY; Yen MHYoung TH

首页> 外文期刊>Biosensors & Bioelectronics: The International Journal for the Professional Involved with Research, Technology and Applications of Biosensers and Related Devices >Electrotaxis of lung cancer cells in a multiple-electric-field chip

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Electrotaxis of lung cancer cells in a multiple-electric-field chip

机译：晴性肺癌细胞的multiple-electric-field芯片

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摘要

We report a microfluidic cell culture chip that was used for long-term electrotaxis study on a microscope. The cellular response under three different electric field strengths was studied in a single channel microfluidic chip. Electric field (EF) inside the microchamber was numerically simulated and compared to the measured value. Lung cancer cell lines with high and weak metastasis potential, CL1-5 and CLI-0. respectively, were used to demonstrate the function of the multi-field chip (MFC). The two cell lines exhibited greatly different response under the applied EF of E = 74-375 mV/mm. CL1-5 cells migrated toward the anode while CL1-0 cells did not show obvious response. Under the applied EF, cell orientation was observed accompanying the cell migration. judging from the different temporal responses of the orientation and the migration, it is proposed that the two EF-induced responses may involve different signaling pathways.

机译：我们报告一个微流控细胞培养芯片是用于长期晴性研究显微镜。不同的电场强度进行了研究单通道微流控芯片。字段(EF) microchamber内数值模拟和比较测量值。和疲软的转移潜力,CL1-5 CLI-0。分别被用来演示多芯片的函数(MFC)。细胞系表现出极大的不同反应应用EF的E = 74 - 375 mV /毫米。细胞向阳极迁移而CL1-0细胞并没有显示出明显的反应。英孚,观察细胞取向陪同细胞迁移。时间取向和反应迁移,提出两个EF-induced反应可能涉及不同的信号通路。

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《Biosensors & Bioelectronics: The International Journal for the Professional Involved with Research, Technology and Applications of Biosensers and Related Devices》 |2009年第12期|3510-3516|共7页
作者
Huang CW; Cheng JY; Yen MHYoung TH;
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作者单位

Natl Taiwan Univ, Inst Biomed Engn, Taipei, Taiwan.;

Acad Sinica Taiwan, Res Ctr Appl Sci, Taipei 11529, Taiwan.;

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正文语种英语
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关键词
Cell Line; Microfluidics; Neoplasm Metastasiscancer cellLung CancerDNA Microarrays;

机译：细胞系;微流体;肿瘤Metastasiscancer;

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Electrotaxis of lung cancer cells in a multiple-electric-field chip

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