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首页> 外文期刊>Israel journal of chemistry >Directed Evolution of Artificial Metalloenzymes
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Directed Evolution of Artificial Metalloenzymes

机译：定向人工进化中近年

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摘要

Transition metal catalysis in asymmetric transformations plays a pivotal role in modern synthetic organic chemistry, with these catalysts being tuned by systematic variation of the chiral ligand. More than three decades ago it was recognized that an alternative approach is possible, namely the anchoring of an achiral ligand/metal entity in an appropriate protein host, with formation of an artificial metalloenzyme (hybrid catalyst). However, this procedure delivers a single transition metal catalyst, with high enantioselectivity being a matter of chance. In view of this restriction, we proposed in 2001/2002 the concept of directed evolution of such hybrid catalysts. The most intensively studied system involves biotinylated phosphine/metal entities which are non-covalently anchored to streptavidin. The present review summarizes progress in this intriguing area of research. It includes the assessment of the requirements of a given Darwinian system to be successful, and offers hints on how to achieve success in future studies.
机译：过渡金属催化的不对称在现代转换中扮演着关键的角色合成有机化学,这些催化剂被系统变化的手性调整配体。认识到另一种方法可能的,即非手性的锚定配体/金属实体在一个适当的蛋白质主机,形成的一个人工金属酶(混合催化剂)。程序提供了一个过渡金属催化剂,具有高选择性机会的问题。提出了在2001/2002定向的概念进化的混合催化剂。深入研究了系统涉及生物素化的磷化氢/金属非共价的实体链霉亲和素的锚定。总结了进展在这个有趣的领域研究。达尔文系统给定的要求如何实现成功,提供了线索在未来的研究的成功。

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