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首页> 外文期刊>Shock: Molecular, cellular, and systemic pathobiological aspects and therapeutic approaches = The official journal of the Shock Society, the European Shock Society, the Brazilian Shock Society, the International Federation of Shock Societies >Effects of a novel antioxidant during resuscitation from severe blunt chest trauma.
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Effects of a novel antioxidant during resuscitation from severe blunt chest trauma.

机译：小说中抗氧化的影响从严重的胸部钝伤复苏。

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Previous work suggests that neutrophils (PMNs) and/or prostaglandins might mediate the progressive respiratory failure after severe pulmonary contusion. Since reactive oxygen metabolites are closely associated with both these factors, we examined the actions of a novel antioxidant after swine received a unilateral injury followed by 25% hemorrhage. An infusion (2mL/kg/h intravenously x 6 h) of either polynitroxylated 5% Dextran + Tempol (PND, n = 9), 5% Dextran (D, n = 6), or lactated Ringers (LR, n = 13) was begun 60 min post-injury to mimic 'pre-hospital resuscitation.' After 15 min, standard resuscitation was initiated (3x shed blood as LR in 30 min) plus further LR for 6 h to maintain hemodynamics. The total LR requirement was lower with PND (1,772+/-267 mL) versus D (3,040+/-689, P = 0.0563) or LR (4145+/-398, P = 0.0005). The ipsilateral bronchoalveolar lavage (BAL) PMN count with PND (8+/-2 x 10(5)/mL), was not different from its baseline (P = 0.131), but the counts with D (16+/-3) and LR (17+/-4) were both higher than their baselines (P = 0.0184 and 0.0431). Similarly, BAL protein with PND (1,560+/-350 mg %) was not elevated from its baseline (P = 0.0721), but the values with D (2,560+/-498) and LR (2,474+/-899) were both higher than their baselines (P = 0.0169 and 0.0325). In the contralateral (uninjured) lung, the effects were similar, but the increases were less for PMNs (8+/-2 versus 10+/-2 or 14+/-4 x 10(5)/mL) and for protein (609 +/-153 versus 1,955+/-671 or 1486+/-357 mg %). Despite these significant BAL changes, there was no obvious improvement in cardiopulmonary dysfunction. Thus oxidants probably have some role in the pathogenic mechanism of progressive secondary injury after thoracic trauma, but further work is needed to determine the therapeutic potential of antioxidants because no clinical improvement was detected.
机译：以前的工作表明,中性粒细胞(中性粒细胞)和/或前列腺素可能调解进步后呼吸衰竭严重肺挫伤。代谢物是紧密联系在一起这些因素,我们研究了小说的行动抗氧化剂后猪单方面受伤之后,25%的出血。静脉注射(2 ml / kg / h x 6 h)polynitroxylated 5% + Tempol (PND葡聚糖,n =9), 5%右旋糖酐(D, n = 6),或乳酸林格氏液(LR, n = 13)开始具有抑制受损,延伸60分钟模仿“院前急救”。标准的复苏开始(3 x血液的LR 30分钟)+进一步LR 6 h维持血液动力学。降低了患产后抑郁症(1772 + / -267毫升)和D0.0005)。(BAL)中性粒细胞计数与患产后抑郁症(8 + / 2 x 10(5) /毫升),不同于其基线(P = 0.131),但是计数与D(16 + / 3)和LR (17 + / 4)都高于基线(P = 0.0184,0.0431)。(1560 + / -350毫克%)没有从其升高基线(P = 0.0721),但与D值(2560 + / -498)和LR (2474 + / -899)比他们的基线(P = 0.0169和更高0.0325)。影响是类似的,但增加中性粒细胞减少(8 + / 2和10 + / 2或14 + / 4 x10(5) /毫升)和蛋白质(609 + / -153对1955 + -671或1486 + / -357毫克%)。落下帷幕的重大变化,没有明显的改善心肺功能障碍。氧化剂可能有一定作用发病机理的进步次要的胸外伤后受伤,但进一步的工作需要确定的治疗潜力抗氧化剂因为没有临床改善检测到。

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