...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Shock: Molecular, cellular, and systemic pathobiological aspects and therapeutic approaches = The official journal of the Shock Society, the European Shock Society, the Brazilian Shock Society, the International Federation of Shock Societies >Comparison of the effects of bolus vs. slow infusion of 7.5% NaCl/6% dextran-70 in a model of near-lethal uncontrolled hemorrhage.
【24h】

Comparison of the effects of bolus vs. slow infusion of 7.5% NaCl/6% dextran-70 in a model of near-lethal uncontrolled hemorrhage.

机译：丸的影响与比较缓慢注入7.5%生理盐水/ 6%右旋糖酐- 70的模型近乎致命不可控出血。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Bolus infusion of of 7.5% NaCl/6% dextran-70 (HSD-B) improves outcome from controlled hemorrhage. In contrast, HSD-B during uncontrolled hemorrhage increases bleeding and short-term mortality. The purpose of this study was to compare the effects of bolus vs. slow infusion of HSD in a near-fatal vascular injury hemorrhage model. Sixteen (15-20 kg) swine with 4-mm aortic tears were hemorrhaged to a pulse pressure of 5 mmHg. An ultrasonic flow probe was placed proximal to the aortic tear for continuous blood flow (AF) measurements. Group I (slow infusion; n = 8) was resuscitated with 8 mL/kg of HSD at 0.4 mL/kg/min. Group II (bolus infusion; n = 8) was resuscitated with 8 mL/kg of HSD at 1.33 mL/kg/min. In both groups, HSD infusion was followed by administration of 30 mL/kg of shed blood at 3 mL/kg/min. Hemorrhage volume and 90-min mortality were greater in group II (79+/-11 mL/kg; 75%) compared with group I (43+/-9 mL/kg; 12.5%) (P(Hem) < 0.001; P(Mort) = 0.04). Mean arterial pressure (MAP) and AF were greater in group II compared with group I during the first 15 min of resuscitation. In group I, MAP, AF, cardiac indices, and O2 delivery gradually returned to baseline levels and were significantly greater than group II at 30 min and throughout the remainder of the protocol. In this model of near-lethal uncontrolled hemorrhage, slow infusion of HSD restored cardiodynamics while minimizing hemorrhage volume and mortality. Resuscitation regimens that cause early increases in blood flow and pressure may result in greater hemorrhage and mortality than those regimens that yield comparable flow and pressure increases late in resuscitation.
机译：丸注入7.5%生理盐水/ 6%右旋糖酐- 70从控制(HSD-B)改善结果出血。不受控制的出血和出血增加短期死亡率。是比较丸的影响与慢注入的HSD几乎致命的血管损伤出血模型。4毫米主动脉脉冲泪水泄露5毫米汞柱的压力。放置近端为连续主动脉撕裂血流量(AF)测量。输液;HSD 0.4 mL / kg /分钟。= 8)和8毫升/公斤HSD复苏为1.33毫升/公斤/分钟。其次是管理30毫升/公斤血3毫升/公斤/分钟。90 - min死亡率是更大的在第二组(79 + / -11毫升/公斤;(43 + / 9毫升/公斤;0.04)。更大的在组II相比,组我第一个15分钟的复苏。地图,房颤,心脏指数,和O2交付逐渐恢复到基线水平,明显大于组II在30分钟在剩下的协议。近乎致命的模型无法控制的出血,缓慢注入HSD恢复心脏动力学同时最小化出血数量和死亡率。早期复苏方案导致增加血流量和压力可能会导致更大的出血和死亡率比方案产量可比流量和压力增加在复苏。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号