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首页> 外文期刊>Shock: Molecular, cellular, and systemic pathobiological aspects and therapeutic approaches = The official journal of the Shock Society, the European Shock Society, the Brazilian Shock Society, the International Federation of Shock Societies >SIRS and MODS: what is their relevance to the science and practice of intensive care?
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SIRS and MODS: what is their relevance to the science and practice of intensive care?

机译：先生们和插件:什么是他们的相关性科学和实践的重症监护?

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SIRS (the Systemic Inflammatory Response Syndrome) and MODS (the Multiple Organ Dysfunction Syndrome) are not diseases or syndromes, but concepts. Common to both is the notion that the morbidity of critical illness arises indirectly, from the response of the host to an acute, life-threatening challenge to systemic homeostasis. The biology of that response is complex and variable, yet implicit in our evolving understanding of systemic inflammation is the possibility that shared biologic mechanisms may permit the development of effective therapy for a wide variety of disorders that appear superficially heterogeneous. The challenge lies in characterizing common pathologic processes or diseases. The four criteria that define SIRS are non-specific measures of physiologic severity, rather than distinctive manifestations of a disease process. Perhaps the use of the systemic correlates of the cardinal manifestations of inflammation developed by Galen and Celsus would provide a more satisfactory clinical characterization of the clinical disorder. However, the complexity of the biologic processes involved suggest that a clinical syndrome of systemic inflammation is of no more use to the clinician than a clinical syndrome of cancer. As the functio laesa of systemic inflammation, organ dysfunction is more appropriately viewed as an undesireable outcome of systemic inflammation, a complication to be prevented, rather than a disease to be treated. As concepts, SIRS and MODS provide a useful intellectual framework for investigation, but the clinician must treat diseases, no acronyms. The challenge will be to characterize these disease.
机译：先生们(全身炎症反应综合征)和插件(多个器官功能障碍综合征)不是疾病或症状,但是概念。关键疾病的发病率产生间接地从响应主机的一种急性、危及生命的系统性的挑战体内平衡。复杂,变量,但是隐含在我们系统性炎症发展的理解共享生物的可能性吗可能允许的发展机制有效治疗各种各样的疾病出现表面上异构。挑战在于共同的特征病理过程或疾病。标准定义不明确的先生们生理指标严重程度,而不是独特的一种疾病过程的表现。也许使用系统性的关联红衣主教炎症发展的表现盖伦和克理索将提供一个更多令人满意的临床特征临床疾病。生物过程表明系统性炎症的临床综合征没有比临床用于临床医生综合症的癌症。系统性炎症、多器官功能障碍适当地视为一个令人不快的结果系统性炎症的并发症预防,而不是一种疾病治疗。提供一个有用的概念,先生们和插件知识框架进行调查,但是临床医生必须治疗疾病,没有首字母缩写。挑战将是描述这些疾病。

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