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首页> 外文期刊>Chemical Engineering Research & Design: Transactions of the Institution of Chemical Engineers >Macro-mixing and Streptomyces fradiae - Modelling oxygen and nutrient segregation in an industrial bioreactor
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Macro-mixing and Streptomyces fradiae - Modelling oxygen and nutrient segregation in an industrial bioreactor

机译：Macro-mixing和链霉菌属fradiae——造型氧气和营养物质隔离在一个工业生物反应器

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摘要

Some illustrative results are presented for a 3 m(3) triple-impeller stirred reactor producing tylosin (using Streptomyces fradiae) being fed with air and a concentrated aqueous ammonium nitrate solution. The analysis is performed for a 3 x 2(10 x 10) configuration of a networks-of-zones model comprising 600 zones. The gas-liquid flows, giving rise to circulation and bubble dispersion, are calculated assuming that bubbles move independently at their rise velocity without distorting the liquid Rows bring generated by tilt: impellers. In this way the gas hold-up distribution in 3-D is obtained from simple continuity principles. Mass transfer and a 2nd order bioreaction may then be combined with gas-liquid flow to predict the spatial distribution of the (pseudo-stationary) concentration fields. The observed overall gas voidage. overall oxygen mass transfer and a locally measured dissolved oxygen level are all exactly matched by the simulations. The predicted segregated concentration fields show remarkably complicated patterns. Micro-organisms following stochastic paths around the vessel will experience wide variations in chemical environments. [References: 19]
机译：提出了一些说明性的结果3(3) triple-impeller搅拌反应器生产泰乐菌素(使用链霉菌属fradiae)空气和集中水铵硝酸溶液。3 x 2 (10 x 10)的配置networks-of-zones模型由600区。气液流动,引起循环和泡沫分散,计算假设泡沫独立活动的上升速度没有液体行带来扭曲产生的倾斜:叶轮。滞留在获得三维分布简单的连续性原则。二阶问题可以结合气液流量预测的空间分布(pseudo-stationary)集中的领域。空隙率。都是本地测量溶解氧水平完全匹配的模拟。种族隔离的字段显示显著的浓度复杂的模式。船将随机路径体验化学的巨大差异环境。

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