...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of diabetes. >Prefrontal cortex brain damage and glycemic control in patients with type 2 diabetes
【24h】

Prefrontal cortex brain damage and glycemic control in patients with type 2 diabetes

机译：前额叶皮层脑损伤和血糖控制在2型糖尿病患者

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Background This study examined brain tissue integrity in sites that controls cognition (prefrontal cortices; PFC) and its relationships to glycemic outcomes in adults with type 2 diabetes mellitus (T2DM). Methods We examined 28 T2DM patients (median age 57.1?years; median body mass index [BMI] 30.6 kg/m 2 ;11 males) and 47 healthy controls (median age 55.0?years; median BMI 25.8 kg/m 2 ; 29 males) for cognition (Montreal Cognitive Assessment [MoCA]), glycemic control (hemoglobin A1c [HbA1c]), and PFC tissue status via brain magnetic resonance imaging (MRI). High‐resolution T1‐weighted images were collected using a 3.0‐Tesla MRI scanner, and PFC tissue changes (tissue density) were examined with voxel‐based morphometry procedures. Results Reduced PFC density values were observed in T2DM patients compared to controls (left, 0.41?±?0.02?mm 3 /voxel vs 0.44?±?0.02?mm 3 /voxel, P ??0.001; right, 0.41?±?0.03?mm 3 /voxel vs 0.45?±?0.02?mm 3 /voxel, P ??0.001). PFC density values were positively correlated with cognition; left PFC region (r = 0.53, P = 0.005) and right PFC region (r = 0.56, P = 0.003), with age and sex as covariates. Significant negative correlations were found between PFC densities and HbA1c values; left PFC region (r = ?0.39, P = 0.049) and right PFC region (r = ?0.48, P = 0.01), with age and sex as covariates. Conclusions T2DM patients showed PFC brain tissue damage, which is associated with cognitive deficits and poor glycemic control. Further research is needed to identify causal relationships between HbA1c, cognition, and brain changes in T2DM and to evaluate the impact of interventions to prevent brain tissue injury or neuroregeneration in this high‐risk patient population, to eventually preserve or enhance cognition and improve glucose outcomes.
机译：文摘背景研究了大脑组织完整性控制认知的网站(前额叶皮层;在成人2型血糖的结果糖尿病(2型糖尿病)。2型糖尿病患者(平均年龄57.1年;质量指数(BMI) 30.6公斤/米2;11男性)和47健康对照组(平均年龄55.0年;体重指数25.8公斤/米2;(蒙特利尔认知评估[上海]),血糖控制(糖化血红蛋白(糖化血红蛋白)),PFC组织通过脑磁共振成像状态(MRI)。使用一个3.0特斯拉收集磁共振扫描仪,PFC组织(组织密度)进行更改基于体素检测的形态测量学程序。PFC中观察密度值降低2型糖尿病病人相比,对照组(左)0.41±0.02 ?/体素、P & ? 0.001;0.02 /体素vs 0.45±? ?& ? 0.001)。与认知;0.53, P = 0.005)和右PFC区域(r = 0.56,P = 0.003),与年龄和性别作为协变量。发现了显著的负相关性PFC密度和糖化血红蛋白值之间;区域(r = ? 0.39, P = 0.049)和右PFC区域(r = ? 0.48, P = 0.01),与年龄和性别协变量。与脑组织损伤认知缺陷和血糖控制不佳。这还需要进一步的研究来确定因果关系糖化血红蛋白之间的关系、认知和大脑2型糖尿病和评估变化的影响防止大脑组织损伤或干预本次在这种高危险病人人口,最终保留或增强认知和改善血糖结果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号