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首页> 外文期刊>Journal of diabetes. >Joint impact of muscle mass and waist circumference on type 2 diabetes in Japanese middle-aged adults: The Circulatory Risk in Communities Study (CIRCS)
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Joint impact of muscle mass and waist circumference on type 2 diabetes in Japanese middle-aged adults: The Circulatory Risk in Communities Study (CIRCS)

机译：肌肉和腰部关节的影响周长在日本2型糖尿病中年人:循环的风险社区研究(情况)

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Background Although evidence about skeletal muscle mass loss and type 2 diabetes risk has accumulated, little information is available on the combined effect of skeletal muscle mass and abdominal obesity on type 2 diabetes. We examined whether skeletal muscle mass and abdominal obesity were synergistically associated with the prevalence of type 2 diabetes. Methods Skeletal muscle mass and waist circumference (WC) were measured in 1515 Japanese aged 40 to 69 years. Relative muscle mass was calculated as percentage of total skeletal muscle mass in body weight (SMM%). Type 2 diabetes was identified as fasting serum glucose >= 7.0 mmol/L (126 mg/dL), nonfasting serum glucose >= 11.1 mmol/L (200 mg/dL), glycosylated hemoglobin >= 6.5%, and/or diabetes medication use. Results The multivariable-adjusted odds ratio (OR) of prevalent diabetes from the lowest to the third quartile of SMM% compared to the highest quartile gradually increased in both sexes. The association between a high WC and prevalent diabetes was similar. The multivariable-adjusted OR (95% confidence intervals) for the prevalence of type 2 diabetes in the low skeletal muscle mass/high WC group was 3.19 (1.78-5.71) for men and 4.46 (2.09-9.51) for women compared with the high skeletal muscle mass/low WC group. The relative excess risk due to interaction was 2.2 (0.5-3.9) in men and 2.8 (0.2-5.3) in women for an excess burden of type 2 diabetes for low skeletal muscle mass and high WC. Conclusions Low skeletal muscle mass and abdominal obesity were synergistically associated with presence of type 2 diabetes.
机译：背景虽然对骨骼肌的证据质量损失和2型糖尿病的风险积累,小信息是可用的骨骼肌质量和综合效应腹部肥胖2型糖尿病。是否骨骼肌质量和腹部肥胖是与增效剂2型糖尿病的患病率。肌肉和腰围(WC)以1515年日本40到69岁。相对肌肉百分比计算总骨骼肌肉的体重多发性骨髓瘤(%)。血清葡萄糖> = 7.0更易/ L (126 mg / dL),nonfasting血清葡萄糖> = 11.1更易/ L (200mg / dL),和/或糖化血红蛋白> = 6.5%糖尿病药物的使用。multivariable-adjusted比值比(或)流行的糖尿病从最低到第三四分位数多发性骨髓瘤的%比最高四分位数在两性逐渐增加。高WC和流行之间的联系糖尿病是相似的。或患病率(95%置信区间)2型糖尿病的低骨骼肌质量/高WC组为3.19 (1.78 - -5.71),女性为4.46(2.09 - -9.51)相比骨骼肌质量高/低WC组。相对过剩的风险由于交互是2.2男性(0.5 - -3.9)和2.8(0.2 - -5.3)的女性超额负担低的2型糖尿病骨骼肌质量和高WC。骨骼肌质量和腹部肥胖协同相关类型的存在2糖尿病。

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