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首页> 外文期刊>Journal of diabetes. >Optimal body mass index cut‐off points for prediction of incident diabetes in a Chinese population
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Optimal body mass index cut‐off points for prediction of incident diabetes in a Chinese population

机译：最佳的身体质量指数切断必经点事件预测糖尿病在中国人口

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Abstract Background The current body mass index (BMI) classifications have been established based on the risk of obesity‐related conditions, but not specifically on type 2 diabetes mellitus (T2DM). The aim of this study was to identify the optimal BMI cut‐off points for assessing incident T2DM risk in the Chinese population. Methods The longitudinal study cohort consisted of 8735 non‐diabetic participants aged 20–74?years at baseline, with a mean follow‐up period of 6.0?years. Body mass index, 2‐h plasma glucose after a 75‐g oral glucose tolerance test, and HbA1c were measured at baseline and follow‐up. Results During the follow‐up period, 825 participants were diagnosed with T2DM. In multivariable Cox regression analyses, after adjusting for covariates, a strong positive association between BMI and incident T2DM was found in the whole population; however, when stratified by age groups (20–39, 40–59, and 60–74?years), the risk associations between BMI and incident T2DM decreased with increasing age and were no longer evident in the 60–74?years group ( P interaction ??0.001). The optimal BMI cut‐off points for predicting T2DM risk for men and women were 25.5 and 24.4?kg/m 2 , respectively, in the 20–39?years group, and 23.5 and 23.0?kg/m 2 , respectively, in the 40–59?years group. There was no predictive performance of BMI in the 60–74?years group for either sex. Conclusions The results suggest that the performance of BMI in predicting T2DM risk was best in subjects of younger age and decreased with age. Age‐ and sex‐specific BMI cut‐off points should be considered for T2DM risk stratification in the Chinese population.
机译：抽象的背景目前的身体质量指数(BMI)分类建立了基础在肥胖相关疾病应承担的风险,但是没有特别的2型糖尿病(2型糖尿病)。最优BMI切断必经点评估事件中国人2型糖尿病的风险。纵向研究队列由8735非糖尿病应承担的参与者年龄在20 - 74吗?基线,意味着遵循了里6.0 ?。后一个75 g口服葡萄糖耐量试验,和糖化血红蛋白测定在基线和遵循。结果下了应承担的时期,825年参与者被诊断为2型糖尿病。后,多变量Cox回归分析协变量调整为强阳性BMI和事件2型糖尿病之间的联系发现在整个人口;按年龄分组的分层(热带病,40岁至59岁60 - 74 ?年),风险指数之间的联系二型糖尿病与事件随着年龄的增长而减少不再明显在60 - 74 ?组(P交互& ? 0.001)。BMI切断必经点预测2型糖尿病的风险男人和女人分别为25.5和24.4吗?分别在热带病吗?和23.0吗?40岁至59岁吗?BMI在60 - 74的性能?性。BMI的性能预测2型糖尿病的风险最好在年轻时代的主题和减少随着年龄的增长。点应考虑对2型糖尿病的风险在中国人口分层。

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