Circulating dipeptidyl peptidase-4 activity correlates with measures of hepatocyte apoptosis and fibrosis in non-alcoholic fatty liver disease in type 2 diabetes mellitus and obesity: A dual cohort cross-sectional study

Williams Kathryn H.; De Ribeiro Ana Julia Vieira; Prakoso EmiliaVeillard Anne-SophieShackel Nicholas A.Brooks BelindaBu YangminCavanagh ErikaRaleigh JimMcLennan Susan V.McCaughan Geoffrey W.Keane Fiona M.Zekry AmanyGorrell Mark D.Twigg Stephen M.

首页> 外文期刊>Journal of diabetes >Circulating dipeptidyl peptidase-4 activity correlates with measures of hepatocyte apoptosis and fibrosis in non-alcoholic fatty liver disease in type 2 diabetes mellitus and obesity: A dual cohort cross-sectional study

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Circulating dipeptidyl peptidase-4 activity correlates with measures of hepatocyte apoptosis and fibrosis in non-alcoholic fatty liver disease in type 2 diabetes mellitus and obesity: A dual cohort cross-sectional study

机译：循环dipeptidyl peptidase-4活动与肝细胞凋亡在非酒精脂肪肝和纤维化在2型糖尿病和肥胖:双人群横断面研究

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BackgroundIntrahepatic expression of dipeptidyl peptidase-4 (DPP4), and circulating DPP4 (cDPP4) levels and its enzymatic activity, are increased in non-alcoholic fatty liver disease (NAFLD) and in type 2 diabetes mellitus and/or obesity. DPP4 has been implicated as a causative factor in NAFLD progression but few studies have examined associations between cDPP4 activity and NAFLD severity in humans. This study aimed to examine the relationship of cDPP4 activity with measures of liver disease severity in NAFLD in subjects with diabetes and/or obesity.

机译：BackgroundIntrahepatic dipeptidyl的表达peptidase-4 (DPP4)和循环DPP4 (cDPP4)水平及其酶活性,增加在非酒精脂肪肝(NAFLD)在2型糖尿病和/或肥胖。一直与诱发因素非酒精性脂肪肝进展,但很少有研究cDPP4活动之间的关联和非酒精性脂肪肝人类的严重程度。cDPP4活动与措施之间的关系非酒精性脂肪肝的肝脏疾病严重程度糖尿病患者和/或肥胖。

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《Journal of diabetes》 |2015年第6期|809-819|共11页
作者
Williams Kathryn H.; De Ribeiro Ana Julia Vieira; Prakoso EmiliaVeillard Anne-SophieShackel Nicholas A.Brooks BelindaBu YangminCavanagh ErikaRaleigh JimMcLennan Susan V.McCaughan Geoffrey W.Keane Fiona M.Zekry AmanyGorrell Mark D.Twigg Stephen M.;
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作者单位

Univ New S Wales, Sch Med Sci, Royal Prince Alfred Hosp, Sydney, NSW, Australia;

Univ New S Wales, Sch Med Sci, Inflammat & Infect Res Ctr, Sydney, NSW, Australia;

Univ Sydney, Sydney Nursing Sch, Sydney, NSW 2006, AustraliaUniv Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia;

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正文语种英语
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关键词
Fibrosis; DPP4 gene; Liver DiseasesType 2 Diabetes MellitusDiabetes MellitusDipeptidyl Peptidases;

机译：肝纤维化;DPP4基因;2 DiseasesType糖尿病;

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Circulating dipeptidyl peptidase-4 activity correlates with measures of hepatocyte apoptosis and fibrosis in non-alcoholic fatty liver disease in type 2 diabetes mellitus and obesity: A dual cohort cross-sectional study

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