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首页> 外文期刊>Journal of diabetes >Assessment of baseline characteristics, glycemic control and oral antidiabetic treatment in Asian patients with diabetes: The Registry for Assessing OAD Usage in Diabetes Management (REASON) Asia study
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Assessment of baseline characteristics, glycemic control and oral antidiabetic treatment in Asian patients with diabetes: The Registry for Assessing OAD Usage in Diabetes Management (REASON) Asia study

机译：评估基线特征,血糖控制和口服抗糖尿病的治疗在亚洲糖尿病患者:注册表糖尿病管理评估道路旁边使用(原因)亚洲研究

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Background: To assess baseline characteristics, glycemic control, and treatment with oral antidiabetic drugs (OAD) in type 2 diabetes mellitus (T2DM) patients. Methods: This multinational, observational study recruited patients ≥21 years of age who were newly diagnosed and/or treated with OAD monotherapy for 6 months but were inadequately controlled. In cross-sectional phase, data on demographics, medical history, diabetic complications and comorbidities, OAD treatment, glycosylated hemoglobin (HbA1c), and fasting blood glucose (FBG) were collected. In longitudinal phase evaluating 6-month follow-up of sulfonylurea (SU)-treated patients, additional data on reasons for not achieving HbA1c targets were collected. Results: Of 1487 patients (mean [±SD] age 52.0±11.6 years; 46.7% men; mean BMI 25.8±4.4kg/m2) recruited, 75.9% were newly diagnosed, 73.3% had central obesity, 43.8% had hypertension, and 60.5% had dyslipidemia. The mean HbA1c was 9.8±2.4%, and the mean FBG was 11.3±4.3mmol/L. At T0 (baseline) and T6 (month 6 visit), 99.8% (n=1066) and 97.1% (n=830) patients received SU, respectively. There was decrease from T0 to T6 in mean HbA1c (10.2% vs 7.3%, respectively; P0.0001) and mean FBG (12.0 vs 7.6 mmol/L, respectively; P0.0001). Number of patients with HbA1c 7% increased from T0 (4.5%) to T6 (46.8%). Reasons for not achieving target HbA1c included poor diabetes education (50.7%), non-compliance to OADs (21.4%), and fear of hypoglycemia (19.7%). Conclusion: Marked reductions in HbA1c and FBG are achievable in T2DM patients managed with OADs. However, patient education and compliance are important for achieving and maintaining treatment targets.
机译：背景:评估基线特征,血糖控制,并与口服治疗抗糖尿病的药物(外形尺寸)在2型糖尿病(糖尿病患者。跨国公司,观察研究招募了新病人≥21岁诊断和/或治疗与外形尺寸单一疗法& 6个月,但不充分的控制。代表性的阶段,人口统计的数据,病史、糖尿病并发症和并发症、外形尺寸处理、糖化血红蛋白(HbA1c),空腹血糖(光纤光栅)收集。磺酰脲类的评价6个月随访(苏)治疗患者,附加数据的原因没有实现糖化血红蛋白目标是收集。结果:1487例患者(平均年龄(±SD)52.0±11.6年;25.8±4.4 kg / m2)招募,75.9%新诊断,73.3%有中央肥胖,43.8%的人高血压,60.5%有血脂异常。糖化血红蛋白是9.8±2.4%,意思是光纤光栅11.3±4.3更易/ L。访问),99.8% (n = 1066)和97.1% (n = 830)的病人分别收到苏。在平均糖化血红蛋白从T0 T6 (10.2% vs 7.3%,分别;分别为7.6更易/ L;患者糖化血红蛋白& 从T0增加7%T6(46.8%)(4.5%)。糖化血红蛋白目标包括可怜的糖尿病教育(50.7%),不符合,外形尺寸(21.4%),和恐惧低血糖症(19.7%)。降低糖化血红蛋白和光纤光栅可以实现的与外形尺寸T2DM病人管理。教育和遵从性是重要的实现和维持治疗的目标。

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